; the
comune over which various Barberini family members were given control. The Barberini participated extensively in the
First War of Castro. The conflict began when
Odoardo Farnese,
Duke of Parma and
Piacenza, visited Rome and insulted the pope's nephews by suggesting the brothers were too young to manage the Pope's affairs. The war produced no clear victor, and Pope Urban died in 1644, only months after a peace accord was signed. Despite Urban's appointment of several relatives as cardinals, the
College of Cardinals elected
Pope Innocent X of the
Pamphili family. Almost immediately, Innocent X launched an investigation into the conduct of various members of the Barberini family during the wars. The three nephews who had risen to prominence under their uncle
Pope Urban VIII, cardinals Antonio and Francesco and Prince Taddeo were forced into exile and fled to
Paris under the protection of
Cardinal Mazarin. Antonio and Taddeo left first, by sea, but not before hanging the
French coat of arms above the door of the
Palazzo Barberini to confirm they were under the protection of France. Francesco joined his brothers soon after. Taddeo's wife,
Anna Colonna also joined her husband and children in Paris but not before making a passionate appeal (in person) to the Pope, urging him not to strip the Barberini of their assets. The Pope agreed and, though he paid some debts out of the Barberini estate, left the Barberini alone. In Paris, they relied on the hospitality of
Louis XIV, King of France, until 1653 when most of the family finally returned to Rome. Though Taddeo died in exile in 1647, his brothers eventually reconciled with the papacy through the marriage of Taddeo's younger son
Maffeo with
Olimpia Giustiniani, a niece of Pope Innocent. Maffeo was given his father's former title, that of
Prince of Palestrina. Taddeo's older son
Carlo Barberini was made a cardinal by Pope Innocent X. Taddeo's daughter,
Lucrezia Barberini, married
Francesco I d'Este, Duke of Modena (who had previously sided with the
Farnese during the First War of Castro), further stabilizing relations. == Later history ==