When first known the city was under the control of
Shamshi-Adad I (c. 1813–1776 BC) of the Kingdom of Upper Mesopotamia. In a letter from his son
Ishme-Dagan of
Ekallatum found at Mari: A letter from a ruler of
Eshnunna, thought to be
Ipiq-Adad II or his successor
Naram-Sin of Eshnunna, to Shamshi-Adad I of Ekallatum states: A joint army of Shamshi-Adad I and Dādūša of Ešnunna met at Mankisum before marching down the Tigris to attack the city of
Malgium. In a text to the ruler of Eshnunna it read: After the death of Shamshi-Adad I his kingdom dissolved and many polities in the region were overrun for a time by the Elamites. They moved up the Tigirs to Mankisum but then retreated and instead took
Eshnunna. After the Elamites withdrew from the region it was open to the expansion of Babylon under
Hammurabi (c. 1810-1750 BC). Early in the reign of Hammurabi an Eshnunnan army had invaded the territory of Babylon and a text sent to the ruler of Mari stated, "A mass of troops of the prince of Ešnunna are assembling at Mankisum; Dannum-tahaz will cross the [ri]ver with them and go t[o] Rapiqum". It is known that there was a ford across the Tigris at Mankisum. Early in the reign of Old Babylonian Empire ruler
Hamurabi a conflict between Babylon, Mari, Eshnunna, and Elam resulted in Hamurabi being in control of the
Upi area. A text from
Mari showed diplomacy over that area's disposition: Late in the reign of Hammurabi Babylon entered an expansionist phase which including conquering Mankisum. In his 32nd year name of "Year Hammu-rabi the king, the hero who gains victory for Marduk, defeated with his mighty weapons the entire army and soldiers of Eshnunna,
Subartu and Gutium and conquered the land of Mankisum and the land on the banks of the Tigris up to the border of the Subartu mountains" and the Dadusha of Eshnunna year name "Year in which Dādūša seized Mankisum". The Edict of Ammiṣaduqa (c. 1646–1626 BC), ruler of Babylon, gave tax and debt relief to certain groups in a number of selected places. Four of the places – Idamaraṣ, Mankisum, Šitullum, Suḫûm, and Numḫia – were not Babylonian cites. In Mankisum only "markets" were covered. This is the last attested reference to Mankisum. ==Location==