Many of the details of his career are not known, beyond the fact that Asiaticus was a close friend of the imperial house. He acceded to his first consulship during the reign of
Tiberius, an office he could only have achieved with the acquiescence, if not the act, of the emperor. Tiberius' successor Caligula was also a friend to Asiaticus, and may have granted him estates in
Egypt. Despite this, Asiaticus was invited to sit with Caligula on 24 January 41 at the theatre an hour prior to his assassination. When news of the deed swept through Rome and the identity of the slayers was not yet known, based on Caligula's insult to him, Asiaticus was accused of participating in Caligula's death; he replied, "I wish I had been the man." Nevertheless, some modern historians suspect Asiaticus was an accomplice in Caligula's murder. One point Swan raises is that after Caligula's death, when Asiaticus offered his name to the Senate to succeed Caligula, his candidacy was opposed by one of the known participants in the assassination,
Lucius Annius Vinicianus. Whether or not Asiaticus was involved in Caligula's death, contemporaries such as
Sosibius suspected he was involved. This was doubtlessly the basis for Claudius' antipathy towards Asiaticus. Although Asiaticus accompanied Claudius in 43
on his campaign in Britain, it was arguably because Claudius mistrusted him and wanted Asiaticus where he could keep an eye on him. In a speech to the Senate, where Claudius defended the
adlection of Gaulish men into the Senate, he obliquely disparaged Asiaticus, refusing to mention his name: ==Purchase of the Gardens of Lucullus and downfall==