Jose Mario Pantaleo was born in
Pistoia,
Tuscany, to Ida Melani and Enrico Pantaleo. His father was a successful businessman, though much of the Pantaleo family's wealth was lost as a result of
World War I. In February 1927, Mario, who already had endured a terrible bout of
pneumonia that almost cost his life, and his family emigrated to
Cordoba, Argentina, where Enrico's brother had business interests. Enrico's entrepreneurships didn't work out in Argentina, so in 1931 the family returned to Italy. At that time, Mario already knew his destiny: to be a priest. On December 3, 1944, Padre Mario completed his studies in the seminary of Mattera. Without a fixed destiny in his homeland, and bearing in mind that
Cardinal Antonio Caggiano, leader of the
Roman Catholic Church in Argentina, had asked the
Pope for more clergymen, he went to Saint
Pio of Pietrelcina for counsel. He encouraged Mario, saying, "Go my son, you're following your destiny. You have also been chosen for a singular mission." Pantaleo returned to Argentina in 1948 and lived there the rest of his life. ==Early life in Argentina==