Panettiere had a supporting role in the
Disney Channel Original Movie Tiger Cruise, which starred his sister
Hayden. This was one of two productions featuring both siblings onscreen, the other being
The Forger. Panettiere voiced Periwinkle in the
Nick Jr. show ''
Blue's Clues for its sixth and final season, replacing Kenny Kim. He lent his voice to Racing Stripes. He portrayed the voice of Truman X in The X's. He starred as Luke Malloy in the made-for-television Nickelodeon film The Last Day of Summer'', airing on July 20, 2007. It was released on DVD on August 28, 2007. His next film,
The Perfect Game, was going to be released in theaters on August 8, 2008, but
Lionsgate Films decided to push it back to the spring of 2010.
The Perfect Game is directed by
William Dear, based on the true story of how a group of boys from
Monterrey, Mexico became the first non-U.S. team to win the
Little League World Series. Panettiere also co-starred with
Gavin MacLeod in
The Secrets of Jonathan Sperry, a film directed by
Rich Christiano about faith and friendship. He appeared with
Martin Sheen,
Jamie Lee Curtis, and
Christine Lahti, as Elliott Perry in
Dustin Lance Black's play
8, a reenactment of the
Perry v. Schwarzenegger trial, at the
Wilshire Ebell Theatre on March 3, 2012. The performance was broadcast on
YouTube to raise money for the
American Foundation for Equal Rights. In 2019, Panettiere guest starred in the
AMC network series
The Walking Dead and co-starred in
MTV's
How High 2. ==Death==