Player Mayhew was drafted by the
Buffalo Bills in the tenth round (262nd overall) of the
1988 NFL draft. He left in
free agency the following year and signed with the
Washington Redskins, where he started for them over the next four seasons including in their
Super Bowl XXVI win at the end of the
1991 season.
Executive Mayhew interned for nine months within the Redskins' personnel department in 1999, where he assisted in
scouting players for the team leading up to the
2000 NFL draft. The following year, he worked as a labor operations and legal intern for the NFL league office, That same year, Mayhew was hired by the
Detroit Lions as their senior director of football administration by
Matt Millen before being promoted to assistant
general manager in October 2004. He became the team's general manager upon the firing of Millen in September 2008 and retained that role for eight seasons until being fired following a 1–7 start to the
2015 season. Mayhew spent the 2016 season with the
New York Giants as their director of football operations before joining the
San Francisco 49ers as a senior personnel executive the following year. He was promoted to their vice president of player personnel in 2019. Mayhew was hired as general manager of the
Washington Commanders in January 2021. He served in an advisory role to head coach
Ron Rivera, who had final say in football matters. In January 2024, he was replaced at general manager by
Adam Peters but remained with the team as a senior personnel executive and advisor. ==Personal life==