Following
Marvel Zombies 2, Earth-2149's surviving zombies (
Spider-Man,
Wolverine,
Giant-Man,
Wasp, and
Luke Cage) and
Black Panther are transported to an alternate universe by Malcolm Cortez. The first issue revolves around the attempts of Zombie Spider-Man to cure himself of his condition when he lands on an Earth similar to his own, later designated "Earth-Z". Upon becoming aware that his counterpart from this universe is still in college and that
Kingpin has yet to steal the Lifeline Tablet, the Zombie Spider-Man tries to recover it first to see if he can use it to cure himself and become a hero again. However, alerted by his presence, Kingpin hires the
Sinister Six —
Kraven the Hunter,
Mysterio,
Electro,
Vulture,
Doctor Octopus and
Sandman to create a distraction so he can steal the tablet. However, Zombie Spider-Man ends up killing Kingpin and all the Sinister Six minus Sandman, who in turn brutally kills the Spider-Man of this Earth. Due his actions, however, the zombified members of the Sinister Six kill his friends and Zombie Spider-Man kills them to prevent spreading the contagion. The issue also advances the overarching storyline by having Zombie Giant-Man attack and eat Earth-Z's
Uatu. The second issue follows Earth-Z's
Tony Stark, who is having alcoholism problems and is on the verge of selling Stark International and all patents to the Chinese, two years after Zombie Spider-Man's arrival to Earth-Z. Upon teletransporting himself to Stark International's basement in search of Stark's Inhuman technology, Zombie Giant-Man infects
Happy Hogan, who in turn causes the infection of all people in the building except Tony Stark and
James Rhodes, who makes his way to Tony's office and dons Stark's armor. After killing the zombified
Pepper Potts with nanobots, Tony passes on the Iron Man armor to Rhodes and stays behind to be killed by the zombies while Rhodes leaves the building to destroy the remaining zombies, precluding the contagion from spreading further. The third issue follows Earth-2149's Zombie Wolverine, who makes his way to Japan four years after his arrival to Earth-Z concurrently at the same time Earth-Z's Wolverine and
Kitty Pryde are trying to dismantle the criminal operations of
The Hand. As Zombie Wolverine devours Kitty's ninja pursuers, Zombie Spider-Man rescues Kitty and tells her about the origin of the plague and the vaccine he has created to control Zombie Wolverine's hunger. Meanwhile, Zombie Wolverine kills
Shang-Chi,
Elektra,
Sunfire, and
Iron Fist until Earth-Z's Wolverine appears, engaging in a fight. With the intervention of Kitty Pryde and Zombie Spider-Man, Wolverine manages to kill his zombie counterpart, his zombified victims and lets Zombie Spider-Man to get a sample of his blood to develop a cure, and while he becomes infected through unknown reasons, he resists the hunger and does not spread the contagion. The fourth issue follows the return of Earth-Z's
Hulk to the
Blue Area of the Moon years after Zombie Wolverine's attack on Japan and following his
banishment to
Sakaar by the
Illuminati. Upon arriving along with the
Warbound, Hulk discovers Zombie Giant-Man and the zombified
Inhumans, which leads to the deaths of all the Warbound members and with the former infecting him before he makes his way back to Earth. Back on home, the zombified Hulk starts devouring all citizens he can in
New York City until the Illuminati contact the
Sentry to stop him. However, reverting to his zombified human form, Hulk takes advantage to infect Sentry as well, leading Zombie Spider-Man to realize that things have gone too far and that they must act now. The fifth issue ties these threads together, resolving the fates of all of the original Marvel Zombies. Years after Hulk's attack on NYC, Earth-Z has suffered the same fate Earth-2149 endured and there is no longer life on it, with the
Avengers (Sentry,
Moon Knight,
Thundra,
Quasar,
Super-Skrull,
Namor, and
Quicksilver) revealed to have killed Earth-2149's Wasp, Luke Cage and Black Panther while Zombie Giant-Man is working on a dimensional teleporter to devour more universes. However, thanks to Earth-Z's zombified
Professor X, the Avengers are led to a trap and engage in a battle against Zombie Spider-Man and the New Avengers (Earth-Z's Wolverine, Hulk, Iron Man and Sandman). Zombie Giant-Man then teletransports all of them to Uatu's laboratory to use Sentry to power the teleporter. However, the nanite-infused Sandman ends up killing all zombies present minus Sentry, who is trapped on the teletransporter. At the end, Earth-Z's Uatu reveals himself to be alive and sends the Sentry, the last Earth-Z Marvel Zombie, back through time and space to his arrival on Earth-2149 (the original
Marvel Zombies universe). In doing so, it closes a
time loop, which keeps the virus contained on Earth-2149 and Earth-91126. ==Collected editions==