Mary Emilie Holmes was born April 10, 1850, in
Chester,
Ohio, to the
Rev. Mead Holmes (1819–1906), a
Presbyterian minister and
missionary, and Mary D. Holmes (1819–1890). She was their second child; her brother, Mead Jr., was nine years older. When Mary Emilie was three, the family moved to
Manitowoc, Wisconsin, where the Holmeses did mission work among local
Native Americans and became
abolitionists. Her mother also ran a women's
seminary for two years. Mary Emilie showed an aptitude for language, and by listening in on her brother's lessons had picked up the rudiments of
Greek,
Latin, and
French by the time she was eight years old. She also demonstrated a precocious interest in science, starting her first
herbarium at the age of five and turning her family home (and later her own home) into a
menagerie with her collections of tamed animals, including at different times
squirrels,
chipmunks,
raccoons,
gophers,
foxes,
woodchucks, a
bald eagle,
owls, and various small
birds. Mary Emilie's brother died unexpectedly of a ruptured
blood vessel in April 1863 in
Murfreesboro, Tennessee, while serving as a soldier on the
Union side during the
Civil War. The following year, the family moved to
Rockford,
Illinois where Rev. Holmes became active in
local politics. Mary D. Holmes became secretary of the
Woman's Presbyterian Board of Missions of the Northwest and was active in working for the welfare of
freedmen after the Civil War ended. Mary Emilie got her schooling at
Rockford Female Seminary, which she entered at age 14 and from which she graduated with a certificate in 1868. She then began teaching
Spencerian penmanship at the seminary while she studied for a second certificate, in
organ performance, which she earned in 1870. She later joined her parents in working with freedmen under the auspices of the Presbyterian Board of Missions for Freedmen. ==Teaching and science career==