Mary Musgrove was born in the Creek Indian "Wind Clan" with the Creek name
Coosaponakeesa in Coweta Town along the
Ockmulgee River. She was the daughter of a
Creek Native American woman and Edward Griffin, a trader from
Charles Town in the
Province of Carolina, of English descent. Her mother died when Mary was three years old and, soon after, she was taken into the custody of her grandmother. She later became known by her Christian and married names, Mary Griffin Musgrove Matthews Bosomworth. Coweta was connected by a
trading path to the
Upper Creek town of
Tuckabatchee. It is likely that Coosaponakeesa's family traveled, traded, and lived in both towns and had kin in each town, which may account for some historians considering her a Tuckabatchee Creek. Coosaponakeesa stated she was born in Coweta and lived with the Creeks until the age of seven when she, "was brought Down by her Father from the Indian Nation to Pomponne in South Carolina; There baptized, Educated and bred up in the principles of Christianity." After being baptized, her Christian name became Mary. Mary continued to live in
Pon Pon until the
Yamasee War of 1715 broke out. She then returned to Coweta and her Creek family there. Colonel John Musgrove Sr. was a South Carolina Soldier, trader, and planter. He was employed by the
Carolina Assembly to arrange peace between the Creeks and the Carolina colonists. Accompanying him to Coweta was his teenage son, John Musgrove Jr. Musgrove's party was welcomed in Coweta by "Chieftainess Qua", whom most historians have argued was the elder sister of Brims (Mary's aunt), if not her mother. Col. John Musgrove met with the Coweta headman Brims, whom the colonists had earlier designated as "Emperor" so (that in their eyes, at least) Brims could speak for the other Chiefs or headmen. In talks with Brims, it was decided a young niece from Brims' family would be betrothed to Musgrove's son, so as to maintain the native rules of kinship and reciprocity and thus help reinforce the peace treaty. Colonel Musgrove was married to a Creek woman and, therefore, his son John Musgrove Jr., like Mary, was of "mixed blood." Mary and John Musgrove Jr., married and lived among her Coweta kin, which was the traditional practice of matrilineal cultures such as the Creeks. But in 1725, the couple moved to
Pon Pon, an area now in
Colleton County where Mary's father also had lived and where Mary lived for a period as a girl. By the 1730s, they had three sons, but none of their children lived to adulthood. In 1732, the couple were asked by the Carolina governor and the Yamacraws, a group of Creeks and Yamasees, to start a trading post near the
Savannah River. Their trading post, Cowpen] , was well established by the time
James Oglethorpe (1696–1785) and his colonists landed near Georgia. ==Cultural mediator==