In 1818,
Mayhew Mission was established at Mayhew by
Presbyterians from
Massachusetts under
Cyrus Kingsbury for the purpose of
Christianizing and educating the
Choctaw Indians. The community was named Mayhew in honor of another missionary family from Massachusetts. The population of Mayhew Mission quickly declined after the
Treaty of Dancing Rabbit Creek was signed and the Choctaw people were forced to relocate on the
Trail of Tears. Mayhew Station was the original name given to the community when it was moved from its original site (near
Muldrow, Mississippi) to alongside the tracks of the newly built
Mobile and Ohio Railroad (later
Gulf, Mobile & Ohio Railroad) in the very early 1850s. The original location of the town of Mayhew is now referred to as Old Mayhew, but only a cemetery exists there today. In 1900, the population of Mayhew was 139. Bees, lumber, and hay were shipped from Mayhew and the community also had a
tannery. Mayhew is also referred to as Mayhew Junction, or more commonly as "The Crossroads" by area residents, a reference to when
U.S. Route 82 and
U.S. Route 45 crossed as at-grade two-lane highways. Before the construction of the new U.S. Route 82 and the expansion of U.S. Route 45 to four lanes, the intersection of the original highways was a four way stop. Several bars and service stations, catering to students from the nearby
Mississippi State University, lined the four sides of the original intersection and were torn down when the new expressways were built over a period of several years between 1975 and 1995. The
East Mississippi Community College Golden Triangle Campus is in Mayhew. A post office operated under the name Mayhew from 1833 to 1837, under the name Mayhews Station from 1856 to 1903, and again under the name Mayhew beginning in 1903. In 1960, seven black men from
Little Rock, Arkansas used a restroom at Weaver's Amoco in Osborn, where there was only one restroom, which was for whites only. They were arrested in Mayhew and required to pay a $200 per person bond. According to the law, they faced a maximum penalty of six months in jail and fines of $500 each. The case was widely anticipated as the first test of the state's sit-in law, but was settled when the defendants unexpectedly pleaded guilty and paid a small fine in Starkville the next day. Mayhew was once home to Stover Apiaries, the world's largest
queen bee apiary, which shipped queen bees to beekeepers worldwide. ==Education==