Wyllie "appeared on nearly every popular TV series of the late 1950s and much of the 1960s." as Mrs. Blowers in
Wagon Train in the episode "The Ricky & Laurie Bell Story" and in
The Twilight Zone episode "
The Night of the Meek". That same year, she was cast as Mrs. Shafer in the episode "The Captain's Dilemma" of the CBS military sitcom/drama series,
Hennesey, starring
Jackie Cooper as a
United States Navy physician and
Abby Dalton as nurse Martha Hale. Between 1962 and 1966 Wyllie made four guest appearances on
Perry Mason. Her most substantial role of these was as Ninevah Stone in the episode, "The Case of the Nebulous Nephew" (1963). She also played Marguerite Keith, the owner of a home in the path of a road, in the 1964 episode "The Case of the Ruinous Road". In the 1963–1964 season, Wyllie had a recurring role as Mrs. Kissel in 18 episodes of ABC's family
western series,
The Travels of Jaimie McPheeters, starring child actor
Kurt Russell in the title role. Mark Allen played Matt Kissel, her husband, in nineteen episodes. She was in an episode of the Addams Family [1965] as Mrs. Dragwater. in "Cousin Itt's Problem". * In nine episodes, four of
The Osmonds were cast as the singing sons of the Kissel family, all with given names of books of the
Old Testament, Micah, Deuteronomy, Lamentations, and Leviticus. She played the first-ever
villain in
Star Trek, the
Talosian "Keeper" in the pilot episode, "
The Cage" (1964). Not broadcast in its original form for many years, this material was used in the two-parter, "
The Menagerie" (1966). She also appeared in
Batman alongside
Tallulah Bankhead in one episode “Black Widow Strikes Again” (1967). Wyllie appeared on
ABC's
General Hospital as three different characters-Nurse Doris Roach (1974) who revealed to Lesley Faulkner that her daughter (Laura Vining) was still alive; Antique shop proprietor Hester Frumpkin (1982) who worked for Laura's kidnapper, David Gray; and a brief replacement for
Anna Lee as
Lila Quartermaine (1994). She also played several different characters on both
The Golden Girls and
Designing Women. ==Death==