1992–1998: Early work George began modelling in her early teens, and in 1992 was named Western Australia's Teenage Model of the Year. At the age of 16, George and a friend, Cara Mitchinson, both acted in a mock episode of the popular Australian soap
Home and Away with a video camera, playing
Bobby and
Sophie Simpson; respectively. When the offer of a role on the serial came, George's parents convinced her to relocate from her native Perth to
Sydney and she began lodging with families. George met with casting director
Liz Mullinar and was subsequently cast in the role of
Angel Parrish. She made her first on-screen appearance on 30 March 1993, arriving as a teenage runaway. While playing the role, George made property investments and wrote advice columns for two English
teen magazines. Her role earned her five consecutive
Logie Award nominations, of which she won two. The character became popular among viewers when she was paired up with
Shane Parrish, and to this day they remain one of the soap's most loved couples. George departed
Home and Away on 30 August 1996. She then made a health and fitness video,
Mind, Body and Soul (1996), created a sleepwear line called "An Angel at My Bedside", and had a recurring role on the short-lived 1997
Fox Broadcasting Company television fantasy drama series
Roar, which was filmed in
Queensland, opposite
Heath Ledger. Her fearlessness in performing the show's stunts endeared her to the show's creator,
Shaun Cassidy, who subsequently cast her as the female lead in the pilot
Hollyweird. she was to star alongside
Bodhi Elfman and
Fab Filippo. The pilot was ordered to series, however, the Fox Network's tinkering and delays frustrated Cassidy, who pulled out of the project, saying that Fox had forced him to spend "much of the last year trying to fix something I never viewed as broken in the first place." Ultimately, production never went ahead on the show. George then appeared on the cover and in a nude pictorial for the March 1997 issue of
Australian Playboy. In late 1997, George decided to relocate from Australia to the United States, hoping to establish a career in
Hollywood.
1999–2008: Film breakthrough After a supporting role in
Steven Soderbergh's 1999 neo-noir crime film
The Limey, she was cast in a supporting role, Cleo Miller, in the 2001 black comedy
Sugar & Spice and had a minor role in
David Lynch's critically acclaimed
Mulholland Drive, and was originally cast as Susan Freeman in the American series
Coupling based on the British series
of the same name. After "an audition from hell", George was cast and filmed the pilot, but the network (
NBC) then fired the writers and replaced George and her fellow castmembers
Breckin Meyer and
Emily Rutherfurd with
Rena Sofer,
Colin Ferguson, and
Sonya Walger; respectively. George later commented that she "dodged a bullet" by being replaced before the show aired. She had auditioned to play lead character
Sydney Bristow, but lost out to
Jennifer Garner. When that happened, ABC cast her on
Thieves instead. It was originally planned that George would guest-star for several episodes but she was quickly upgraded to regular. To explain her character's accent (George is Australian), the writers wrote that she was born in the United States but grew up in London. George left the show at the end of the third season, saying that "I got offered a couple of films so I decided to kind've [sic] move on." Her first starring role in a feature film was Kathy Lutz in the 2005 remake of the 1979 horror film,
The Amityville Horror. The film was not well received by critics, but was a major success at the worldwide box office, grossing over $108 million. Despite unfavorable reviews,
Film Threat praised George and her co-star
Ryan Reynolds's performances, stating that they "make a striking couple. Both young and extremely attractive" and that she "does an impeccable American accent, but otherwise she is unremarkable as Kathy Lutz. Her physical beauty is sometimes distracting, but not enough to keep the audience awed by her acting." In March 2006, it was announced that she had been cast in the
NBC comedy-drama series
Lipstick Jungle, based on the
novel of the same name by
Candace Bushnell. George was to play Nico Reilly, the editor-in-chief of
Bonfire Magazine. However, the show underwent significant changes; with George and other castmates being replaced and with executive producers DeAnn Heline and Eileen Heisler, and writers
Rand Ravich and Jill Gordon and director
Nigel Cole all being fired. George had been personally cast by Bushnell, but left in early 2007 when she was offered the
HBO series
In Treatment. Also in 2006, she travelled to Brazil to film the horror-thriller
Turistas (released in the UK and Ireland as
Paradise Lost) with
Josh Duhamel and
Olivia Wilde. In 2007, she landed the lead role, Christine, in the biographical drama
Music Within, opposite
Ron Livingston, which focused on a disability-rights activist in
Portland, Oregon. The film had a limited release. In an interview, she said that she "knew that Christine's a true character, and the woman responsible for Richard Pimentel's sort of success in a way. She was the driving force behind him and behind every good man is a good woman, and Christine was that woman." She starred in the British horror-thriller
WΔZ, and had a prominent role in the film adaptation of
30 Days of Night, directed by
David Slade and co-starring
Josh Hartnett.
2008–2018: Television and critical acclaim George returned to television in 2008 in the
HBO half-hour drama
In Treatment, co-starring
Gabriel Byrne and
Dianne Wiest, receiving a 2009
Golden Globe Award nomination for
Best Supporting Actress – Series, Miniseries, or Television Film, and also received a nomination for "Best Actress" at the 2009
Australian Film Institute Awards. In September 2008, George joined the cast of ''
Grey's Anatomy for eleven episodes as Sadie Harris, a bisexual intern, but in January 2009, it was released that she was leaving the show in a mutual agreement with the producers. Also in 2008, she starred in the film The Betrayed'', which was released at the San Diego Film Festival, and was released
direct-to-video in the United States on 30 June 2009. On 9 November 2009, it was announced that George would guest-star in at least two episodes of Fox's
Lie to Me playing Clara Musso. George also received the lead role in the Australian-British
mystery thriller by
Chris Smith titled
Triangle, which opened to positive reviews. George also starred in the British thriller film
A Lonely Place to Die (2010), directed by
Julian Gilbey. She climbed the mountain
Ben Nevis for her role in the film. In November 2010, George was named the new face of L'Oréal Melbourne Fashion Festival. In 2012, George appeared as Rosie in the Australian TV series
The Slap and as Sam Hunter in the British TV series
Hunted, which was filmed over seven months in London, Scotland and Morocco. An
American adaptation of the series, in which George again played the character Rosie, premièred on the
NBC network in February 2015. A review of the U.S. series in
The New York Times noted George's performance as "particularly beguiling ... As Rosie she is absurd, infuriating, sad, and very funny." In 2017, she was cast opposite
Sean Penn in the television series
The First (2018); created by
Beau Willimon and filmed in
New Orleans, Louisiana. On May 30th 2025, George was named as part of the cast for New Zealand series
Ms. X. ==Other ventures==