Daytime television Sofer first played Lois Marie Cerullo on
General Hospital. Her first appearance was in 1993 as a band manager. However, her first high-profile role was as Rocky McKenzie on the daytime soap opera
Loving (1988–1991). Sofer is perhaps best known for her role as Lois Cerullo on
General Hospital (December 15, 1993 – September 24, 1996). She later returned as a guest star (February 7–17, 1997; September 30 – October 2, 1997). Her portrayal of the outrageous Lois won Sofer a Daytime Emmy Award in 1995 for
Outstanding Supporting Actress in a Drama Series. In May 2013, it was announced that Sofer would join the CBS soap opera
The Bold and the Beautiful, in a newly created role of
Quinn Fuller; her first episode aired on July 12. After nine years on the canvas, Sofer opted to end her run in the role of Quinn; she last aired on August 29, 2022. On September 14, 2023,
People announced Sofer would reprise the role of Lois on
General Hospital after a 26-year absence. On October 24, 2025, it was announced that Sofer had ended her run on
General Hospital as Cerullo.
Primetime television Sofer has appeared in several high-profile
prime time television series in a guest star/supporting cast member roles:
Seinfeld,
Melrose Place,
The Chronicle,
Ed,
Friends,
Spin City,
Blind Justice,
Ghost Whisperer,
24,
NCIS, and
Two and a Half Men. Sofer briefly joined the cast of the
NBC sitcom Just Shoot Me!, playing the character Vicky Costa. The network later cast Sofer in the short-lived
US remake of the UK series
Coupling. Sofer has appeared in the NBC TV series
Heroes as the recurring character
Heidi Petrelli, wife of aspiring politician
Nathan Petrelli (
Adrian Pasdar). She appeared on
Two and a Half Men in 2008, as a former girlfriend of the character
Charlie Harper (
Charlie Sheen). Rena also has guest starred on
Dirty Sexy Money playing an intrepid reporter and played a ghost on
Ghost Whisperer. In early 2010, Sofer began a recurring role on
NCIS as attorney
Margaret Allison Hart, a potential love interest for the character
Leroy Jethro Gibbs (
Mark Harmon). She had a brief guest role on
Bones as a love interest for the character
Seeley Booth (
David Boreanaz). In 2013, Sofer had a publicized appearance on
Once Upon a Time, playing
Snow White's mother.
Film In film, she appeared as a love interest of
Ben Stiller's character in the film
Keeping the Faith, starring
Jenna Elfman, Stiller and
Edward Norton (who also directed). She also played a bride to-be with
Melanie Griffith in
Sidney Lumet's movie
A Stranger Among Us and in Penelope Buitenhuis's movie
The Secret of Hidden Lake. She played the P.E. teacher Ms. Desjarden in the television film adaptation of
Carrie in 2002. She starred in the television movie
Always and Forever which aired October 24, 2009, on the
Hallmark Channel. She has been doing TV movies since 1992, when she starred as Andrea Larson in the television movie
Saved by the Bell: Hawaiian Style. == Personal life ==