After graduating from Howard, Griffith worked as a
clinical social worker. From 1992 to 1993, she worked as a project coordinator for the
National Basketball Players Association's Health Education Project at the
Johns Hopkins University. She later served as a senior program officer for the
Academy for Educational Development from 1998 to 2004, afterwards working in various positions for the Prince George's County Health Department until 2009.
Maryland House of Delegates Griffith was sworn into the Maryland House of Delegates on January 13, 1999. She was a member of the Judiciary Committee until 2002, afterwards serving on the Appropriations Committee until she left the legislature in 2015. The Democratic primary was seen as the most competitive election in the district since Currie's election in
1994, with the Prince George's County establishment backing Currie and area newspapers backing Griffith. Griffith ran on a platform focusing on economic development, jobs, education, and public safety, and ran a "nice" campaign against Currie, whom she considered a friend, by not mentioning his corruption charges to voters. Currie enjoyed a significant fundraising advantage over Griffith, having almost three times the cash on hand as her. Griffith was defeated by Currie in the Democratic primary in June 2014, receiving 37.7 percent of the vote to Currie's 58.7 percent. ;2018 In November 2016, after state senator Ulysses Currie announced he would resign from the Maryland Senate, Griffith applied to serve the remainder of his term in the Maryland Senate. However, Currie rescinded his resignation later in the month a few days before it was sent to go into effect, citing the "political fighting" over the selection of his replacement. In June 2017, after Currie announced that he would not seek re-election in
2018, Griffith announced that she would again run for the Maryland Senate in District 25. She received support from the Prince George's County establishment in her run against state delegate
Angela Angel, whom she defeated in the Democratic primary with 55 percent of the vote. She stepped down as president pro tempore in 2023. During the
2020 Democratic Party presidential primaries, Griffith supported
Joe Biden and served as a co-chair of the Maryland Women for Biden group, alongside
Adrienne A. Jones,
Angela Alsobrooks, and
Yvette Lewis. and House Speaker
Adrienne A. Jones enacting law in 2022 In April 2022, Griffith signed 103 Maryland measures into law together with Republican Governor
Larry Hogan and House Speaker
Adrienne A. Jones. It was the first time that two Black women had taken part in such a ceremony as Maryland's presiding officers. Jones represented the house while Griffith as the President pro tem represented the Maryland Senate. On October 6, 2023, Griffith announced that she would resign from the
Maryland Senate at the end of the month to become the head of the Maryland Hospital Association. She is the organization's fifth president, as well as the first African American woman to hold the position. == Political positions ==