During the early part of the Civil War, Confederate soldiers were often transferred to Memphis via the eastern section of the M&LR. The Confederate army also used the railroad's machine shops at Hopefield to modernize rifles. The railroad desired to complete construction of the central section, but the Confederate government was unable to fund the effort. Union troops burned down the railroad shops at Hopefield on February 19, 1863. The
fall of Vicksburg on July 4, 1863, freed enough Federal forces to attempt the conquest of Little Rock. In August 1863, Union
Major General Frederick Steele assembled two infantry divisions at
Helena, Arkansas while
Brigadier General John Wynn Davidson moved south from
Missouri with a 6,000-man cavalry division. By August 18, Steele's combined force of 13,000 troops (soon reinforced to 14,500) and 57 artillery pieces reached DeValls Bluff. Confederate Major General
Sterling Price defended Little Rock with 7,749 soldiers. After Davidson's cavalry crossed the Arkansas River and defeated the Confederate cavalry in the
Battle of Bayou Fourche on September 10, 1863, Price abandoned Little Rock and Steele's troops marched into the city. Once Steele's Union forces were in occupation of Little Rock, the M&LR became a key link to keep them supplied. Federal steamboats brought supplies up the White River to DeValls Bluff where there was an important depot. From DeValls Bluff the supplies were transported via the M&LR to Little Rock. Confederates launched raids to block the vital railroad, but these were unable to interrupt the supply route for long periods. On July 6, 1864, Confederate partisans managed to derail a train at Hick's Station, while on August 24, 1864, Brigadier General
Joseph O. Shelby's raiders succeeded in damaging the railroad at Ashley's Station. ==Post-war==