MarketMethylpentynol
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Methylpentynol

Methylpentynol is a tertiary pentynol with hypnotic/sedative and anticonvulsant effects and an exceptionally low therapeutic index. It was discovered by Bayer in 1913 and was used shortly thereafter for the treatment of insomnia, but its use was quickly phased out in response to newer drugs with far more favorable safety profiles.

Synthesis
Methylpentynol is prepared by reaction of butanone (MEK) with sodium acetylide in liquid ammonia. This reaction must be done in anhydrous conditions and in an inert atmosphere. ==Applications==
Applications
As building block in the synthesis of: • Phthalofyne (1,2-Benzenedicarboxylic acid, mono(1-ethyl-1-methyl-2-propynyl) ester) [131-67-9] • Anansiol (1-ethyl-1-methylprop-2-ynyl carbamate) [302-66-9] • Bason ( 2-Bromoethynyl-2-butanol) [2028-52-6] == See also ==
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