Seattle Mariners The
Seattle Mariners selected Plassmeyer in the fourth round, with the 118th overall selection, of the
2018 Major League Baseball draft. He signed and was assigned to the Low–A
Everett AquaSox, going 0–1 with a 2.25 ERA and 44 strikeouts in 24 innings pitched. He was a 2018 NWL mid-season All Star.
Tampa Bay Rays On November 8, 2018, the Mariners traded Plassmeyer,
Mike Zunino, and
Guillermo Heredia to the
Tampa Bay Rays in exchange for
Mallex Smith and
Jake Fraley. He began the 2019 season with the Single–A
Bowling Green Hot Rods, for whom he was 2–1 with a 1.23 ERA. He was a 2019 MiLB organization All Star, and finished the year making appearances for the High–A
Charlotte Stone Crabs and Triple–A
Durham Bulls. In 25 total games (23 starts), he accumulated a 9–3 record and 1.91 ERA with 109 strikeouts in 132 innings of work. He returned to action in 2021 for the Double–A
Montgomery Biscuits, for whom he logged a 3.64 ERA across 7 contests.
San Francisco Giants On June 11, 2021, the Rays traded Plassmeyer to the
San Francisco Giants in exchange for pitcher
Matt Wisler. Playing for the Triple–A
Sacramento River Cats, Plassmeyer worked with
pitching coach Garvin Alston to make mechanical adjustments to his pitching motion.
Philadelphia Phillies The Giants traded Plassmeyer to the
Philadelphia Phillies in exchange for
Austin Wynns on June 8, 2022. Assigned to the Triple–A
Lehigh Valley IronPigs, Plassmeyer continued working on his mechanical adjustments with IronPigs pitching coach
Cesar Ramos. On August 23 he made his debut, pitching perfect innings, striking out
Austin Romine on three pitches with the bases loaded. Plassmeyer was optioned to Triple-A Lehigh Valley to begin the 2023 season. In 11 games (10 starts), he struggled to a 6.95 ERA with 47 strikeouts in 44 innings of work. On June 20, 2023, Plassmeyer was released by the Phillies. Plassmeyer re–signed with the Phillies on a minor league contract on June 23. On September 30, the Phillies selected Plassmeyer's contract, adding him back to the major league roster. That day he made his first MLB start against the
New York Mets, surrendering 10 runs (9 earned) on 8 hits with 4 strikeouts across innings pitched. Following the season on November 6, Plassmeyer was removed from the 40–man roster and sent outright to Triple–A Lehigh Valley. He elected free agency the same day.
Pittsburgh Pirates On January 4, 2024, Plassmeyer signed a minor league contract with the
Pittsburgh Pirates. In 28 games (11 starts) for the Triple–A
Indianapolis Indians, he struggled to a 5–10 record and 7.93 ERA with innings pitched. Plassmeyer elected free agency following the season on November 4.
Texas Rangers On December 10, 2024, Plassmeyer signed a minor league contract with the
Texas Rangers. He made 28 appearances (16 starts) for the Triple-A
Round Rock Express in 2025, registering a 9-4 record and 4.43 ERA with 99 strikeouts across innings pitched. Plassmeyer elected free agency following the season on November 6, 2025.
Toronto Blue Jays On December 6, 2025, Plassmeyer signed a minor league contract with the
Toronto Blue Jays. ==Personal life==