Kakiouzis made his debut with the
Ionikos N.F. senior club in the 1992–93 season. He played three seasons in the
Greek 2nd Division. At the age of 18, he became the 2nd scorer and rebounder of the Greek 2nd Division. He was in the squad that brought Greece the gold medal at the
1995 FIBA Under-19 World Cup for junior men. This was a stepping stone for his journey toward
AEK Athens, as his performance at the 1995 Junior World Cup with Greece got him a contract with AEK, one of the powers of the top
Greek League. Kakiouzis had a fruitful stay at AEK Athens. While with the club, he won a
Greek League championship in the 2001–02 season, and he also won two
Greek Cups, in the years 2000 and 2001. He also won the
Saporta Cup with AEK, in the year 2000. After leaving AEK Athens in the year 2002, Kakiouzis went on to play for
Montepaschi Siena in
Italy. With Siena, he won both the
Italian League championship and the
Italian Supercup in the 2003–04 season. He was also named to the All-Italian League Team for the season by the
Eurobasket.com website. In 2005, Kakiouzis left Siena and joined
Barcelona Basquet of the
Spanish League. He stayed with Barcelona until his contract expired in 2007. He then joined the Spanish League club
Sevilla. Kakiouzis signed with the
Turkish League club
Efes in 2008. On August 27, 2009, he returned to the Greek League and signed with
Aris Thessaloniki. In 2011, he signed with
Vanoli Basket to help the team to avoid
relegation. In January 2012, he signed with the Italian League club
Virtus Roma. In October 2012, he signed with
SAV Vacallo Basket of the
Swiss League. In 2013, he played for the
Cypriot League club
AEK Larnaca. In the summer of 2013, he participated in the training camp of
Olympiacos. He then joined the Greek club
AENK in 2013. On 19 January 2015, after averaging 9 points and 6 rebounds, he left AENK. On 23 January 2015, Kakiouzis moved to Cyprus and signed a contract with
APOEL. He joined the
Greek 2nd Division club,
Faros Keratsiniou, for the 2015–16 season. On 4 January 2016, he announced that his retirement as a player would come at the end of the 2015–16 season. ==National team career==