Like all elapids in Brazil,
Micrurus frontalis has post-synaptic neurotoxins (except for
Micrurus corallinus) that bind to terminal motor acetylcholine receptors, the toxin is composed of low
molecular weight polypeptides, which are rapidly absorbed by the body after inoculation and symptoms can appear in minutes, the toxin acts peripherally, blocking
neuromuscular transmission. Muscle paralysis is a consequence of the action of the toxin with the neurotransmitter by the
nicotinic receptor on the end plate. At the site of the bite,
edema and
paresthesias occur, the initial systemic symptoms of most coral accidents, include eyelid
ptosis and
diplopia, which are followed by facial muscle paralysis, visual impairment,
anisocoria,
dysarthria,
dysphagia,
salivation and generalized loss of muscle strength, in severe cases, life-threatening
respiratory arrest occurs, with patients requiring
artificial ventilation. The median lethal dose is 22 μg for mice weighing 4–29 grams, and 0.69 mg/kg. The estimates of average yield range between 10 and 30 mg (dry weight), depending on the source. == References ==