United Nations negotiator Edward Douglas survives a
plane crash in the
Java Sea. A passing boat rescues him. Aboard, Dr. Montgomery tends to him and promises that Douglas will be taken to
Timor. However, when they arrive at Montgomery's destination, "Moreau's Island", he instead advises Douglas to disembark and use the
radio there. Douglas and Montgomery go to the Main House, where the former is warned not to wander. According to Montgomery, Moreau vanished after becoming obsessed with his animal research. For his own safety, Douglas is locked in his room by Montgomery, but escapes that night. While exploring, he hears cries and enters a
laboratory where he witnesses a human/
llama mutant give birth, with doctors attending to the delivery. Douglas's presence is noticed by a doctor, who turns out to be a human/animal hybrid, and he flees, finding Aissa, a daughter of Moreau's, who leads him to the 'village' of the mutants. There, Moreau is worshipped by the mutants. He keeps the hybrids subjugated by using a remote-controlled electrical implant, surgically placed at birth under their skin. Moreau tells Douglas how he introduced human
DNA into animals in search of a higher being, incapable of harm. The existing Beast-Folk are imperfect, but Moreau claims to be close to a "solution". Meanwhile, his son Azazello finds a half-eaten
rabbit. After learning of the rabbit, Moreau (who forbids meat-eating) promises that there will be a "
trial" the next day. Douglas tries to escape by boat, but stops as it is overrun with humanoid
rats. At the outdoor trial,
leopard/human hybrid Lo-Mai runs at Moreau but is stopped by the remote-controlled implant. To Moreau's shock, Azazello shoots Lo-Mai dead. His body is
cremated publicly. Inspecting the charred remains, the mutant "
Hyena-
Swine" notices the control implant embedded in Lo-Mai's arm. He then feels for the same implant on his own body and removes it from the bone, feeling pain. Hyena later starts saying "no more pain", wanting to spread the word to all the mutants. In addition to the pain, the animals are controlled through regular drugging to prevent them from "retrogressing". Hyena-Swine reveals his removed implant to Montgomery who sets the other beasts after him. Meanwhile, Douglas tries to contact the outside world, but Montgomery sabotages the radio. Hyena-Swine and his trackers—now on his side and also free of implants—confront Moreau. Enraged, Hyena-Swine reveals his intent to
overthrow him and
destroy all humanity. The group eventually kills Moreau. Douglas then fires a gunshot, scaring the group off. Azazello steals Montgomery's
handgun and joins Hyena-Swine's faction. Aissa informs Douglas that she is regressing: her pupils are
cat-like, her canine teeth are becoming fangs, and her fingernails are becoming sharper. Douglas can stop this with a serum from the lab. However, Montgomery has gone insane and destroyed it. Moreau was planning to use Douglas's DNA to stop Aissa's regression permanently, completing his experiments. Azazello leads the mutants to the
armory. They eventually take over the island, keeping hostages. Montgomery has lost his mind and is promoting
hedonism amongst the mutants. Drunk, he sits in Moreau's former throne and is killed by Azazello while watching a mutant
orgy. Hyena-Swine's group continues to rampage around the island. Azazello hangs Aissa out of
jealousy before being executed by Hyena-Swine, being viewed as a threat to his dominance. Douglas survives by telling Hyena-Swine to impose his leadership and be "God Number One" among the others of his faction, causing Hyena-Swine to kill his supporters. Eventually, M'Ling, another one of Moreau's sons, triggers an explosion that causes Hyena-Swine to lose his gun and allows Douglas to escape. Outnumbered and defenseless, Hyena-Swine retreats into the burning building and dies. Peaceful-minded mutants see off Douglas, who leaves on a raft. The hybrids now want to return to their natural state of being and are in favor of ending Moreau's work. ==Cast==