Toussaint enrolled at the
University of Michigan on a football scholarship in 2009. He was redshirted during the 2009 season. Toussaint missed the first three games of the 2010 season with a knee injury. In his first appearance for the Wolverines, Toussaint rushed for 129 yards on six carries, including a 61-yard gain in the fourth quarter, against
Bowling Green. He suffered a shoulder injury in October 2010.
2011 season After spending the 2010 season as a back-up to
Michael Shaw, Toussaint challenged Shaw for the starting running back position during 2011 summer practice. In the end, head coach
Brady Hoke named Toussaint as the Wolverines' No. 1 running back at the start of the 2011 season. After gaining 80 yards on 11 carries (7.3 yards per carry) and scoring two touchdowns in Michigan's 2011 season opener against
Western Michigan, Hoke confirmed that Toussaint remained the team's No. 1 running back. After suffering a shoulder injury, he did not play against
Notre Dame in the second week of the season. He returned to the lineup the following week and went on to record his second 100-yard rushing game in the
Battle for the Little Brown Jug against
Minnesota in the fifth game of the season, totaling 108 yards on 11 carries for an average of 9.8 yards per carry. On October 29, Toussaint ran for 170 yards and two touchdowns on 20 carries in a 36–14 victory over
Purdue. He had career highs in both yards gained and carries. On November 12, Toussaint set new career highs with 27 carries, a 65-yard run, and 192 rushing yards against
Illinois. In the subsequent two weeks, he followed up with 138 rushing yards against
Nebraska on November 19, 2011, and 120 yards rushing against
Ohio State on November 26, in "
The Game". Toussaint rushed for 1,041 yards in the 2011 season. With quarterback
Denard Robinson also rushing for over 1,000 yards, the Wolverines had a tandem of 1,000-yard rushers for the first time since
1975. Toussaint averaged 5.6 yards per carry during the season. He ranked second in the
Big Ten Conference in yards per carry behind Wisconsin running back
Montee Ball. He earned All-Big Ten Conference honorable mention recognition from both the coaches and the media. At the end of the regular season, Michigan offensive coordinator
Al Borges praised Toussaint's late season performance (100-plus rushing yards in four of the last five games) and compared him to USC Heisman Trophy winner Charles White: "You put the (USC) jersey on him, you would hardly be able to tell the difference. That's who he reminds me of."
2012 season At the time of Michigan's spring practice in April 2012, Borges said there was no running back controversy for the 2012 team: "Fitz is our tailback. If he isn't, I'm not very smart." On July 21, 2012, Toussaint was arrested in Ann Arbor after running a red light and charged with
driving under the influence. On July 23, he was suspended from the team. In late August, Toussaint pleaded guilty to operating a vehicle while visibly impaired, after telling the court that he had been drinking brandy before driving. On October 23, he was sentenced to 10 months probation and ordered by the Court to attend 10
Alcoholics Anonymous meetings, pay $1,500 in fees and fines, and undergo random drug and alcohol tests. Toussaint remained suspended from the team for the opening game of the 2012 season, but returned to the lineup as Michigan's lead running back in the second week of the season against Air Force. Through the tenth game of the 2012 season, Toussaint had gained 483 yards and scored five touchdown on 127 carries, an average of 3.8 yards per carry. On November 17, 2012, during a first quarter run in the game against the Iowa Hawkeyes, Toussaint sustained a broken leg, ending his season.
2013 season After successful rehabilitation on his leg injury, Toussaint returned as the starting running back for the
2013 Michigan Wolverines football team. Through the first two games of the season, he had 128 rushing yards on 36 carries, including 71 rushing yards on 22 carries in Michigan's 41–30 victory over
Notre Dame on September 7, 2013. On October 19, against
Indiana, he had 32 carries for 151 rushing yards and four rushing touchdowns. He finished his final season with the Wolverines with 185 carries for 648 rushing yards and 13 rushing touchdowns. ==Professional career==