MS 26 begins in
Pearl River County at the
Louisiana state line at a bridge over the
Pearl River, where it continues west across the bridge into
Bogalusa as
Louisiana Highway 10 (LA 10). It heads east through woodlands for a couple miles to pass through the community of
Crossroads, where it has an intersection with
MS 43, before passing through rural for the next several miles, where it crosses White Sand Creek. The highway travels through the suburb of
West Poplarville before entering the town of
Poplarville, bypassing downtown to the south as it has an intersection with
US 11 (where it becomes
concurrent (overlapped) with
MS 53) and crosses a bridge over some railroad tracks. MS 26 now passes through a business district, where MS 53 splits off, before having an interchange with
I-59 (Exit 29) before leaving Poplarville and crossing the
Wolf River. The highway travels through rural woodlands before entering
Stone County. MS 26 travels through a mix of farmland and wooded areas for several miles to cross Black Creek before entering the town of
Wiggins. It passes through some neighborhoods before passing by the town's airport and having an interchange with
US 49. The highway passes through more neighborhoods as Central Avenue before passing along the southern edge of downtown as it has an interchange between
MS 29 and
MS 149. MS 26 passes through more neighborhoods before leaving Wiggins and traveling through farmland for the next several miles. The highway passes through the community of
Whites Crossing before traveling through the southern portion of
De Soto National Forest, where it has an intersection with the southern section of
MS 15, before entering
George County. MS 26 crosses Cypress Creek before traveling through the community of
Benndale, where it has a junction with
MS 57. It now crosses the
Pascagoula River, and passes through the community of
Crossroads, before having an interchange with
MS 63 to enter the town of
Lucedale along Winter Street. The highway passes through a business district, where it has an intersection with Old Highway 63 before entering downtown, where it comes to an end at an intersection with
MS 198 (Main Street). The entire length of Mississippi Highway 26 is a rural two-lane highway. ==History==