MS 63 begins in
Jackson County in
Pascagoula at an interchange with
US 90, with the road continuing south into an industrial park as
MS 611. It heads north as a four-lane divided highway to immediately leave Pascagoula and enter neighboring
Moss Point, where it passes through some neighborhoods to have an intersection with Grierson Street (unsigned
MS 618) and cross over the
Escatawpa River. The highway travels through a business district before having an interchange with
I-10 (Exit 69) and passing by the
Trent Lott International Airport. MS 63 now leaves Moss Point and heads north through rural areas, parallel to the
Pascagoula River, for the next several miles, passing through the communities of
Escatawpa (where it has an intersection with
MS 613 and passes by
Plant Daniel) and
Wade (where it has an intersection with
MS 614) before crossing into
George County. MS 63 continues north through rural farmland for several miles to have an intersection with Old Highway 63 before following an
expressway grade bypass of the town of
Lucedale, passing through the western side of town as it has an interchange with
MS 26, crosses over
MS 198 without an interchange or connection of any kind, and an interchange with
US 98. It now leaves the Lucedale area and travels through woodlands for a couple miles to cross into
Greene County. MS 63 continues through woodlands for the next several miles (part of the
Kurtz State Forest) to an interchange between
MS 57 and
MS 594 (Old Highway 63), with the expressway continuing north along MS 57, and MS 63 becomes
concurrent (overlapped) with MS 57 southbound and they head northwest as a two-lane highway to have an intersection with Old Highway 57 before crossing the
Chickasawhay River into the town of
Leakesville. MS 57/MS 63 travel straight through downtown along Main Street (passing by the Greene County Courthouse) before the two highways split on the western side of town, with MS 63 heading northwest to pass by the
South Mississippi Correctional Institution before cutting in-and-out of the
De Soto National Forest for the next several miles. The highway travels through the community of
Sand Hill, where it has an intersection and short concurrency with
MS 42, before crossing into
Wayne County. MS 63 now travels through a large tract of the National Forest, where it has an intersection with Strickland Road (unsigned
MS 536), before leaving the National Forest permanently and winding its way northeast through the community of
Clara before crossing the Chickasawhay River for a second time to enter the city of
Waynesboro. The highway passes through neighborhoods along Turner Street before entering downtown and coming to an end at an intersection with
MS 184 (Azalea Drive). ==History==