• Sovereign Bill as Molly Mabray, the series' titular character. She is of
Gwich'in,
Koyukon, and
Dena'ina Athabascan descent. She has a blog to share with viewers in the lower 49 states about life in Alaska. Her native name is Shahnyaa, which means "one who informs us". She also has a
sled dog named Suki. • Sequoia Janvier (season 1), Zane Jasper (seasons 2–3) and Nash Weekusk (season 4) as Tokone "Tooey" Ookami (Japanese: トコネ 「トゥーイ 」狼), Molly’s best friend (besides Trini). He is of Yupik, Koyukon, and Japanese descent. His last name means "wolf" in Japanese. In "Porcupine Slippers", Atsaq refers to Tooey as "Little Wolf". • Vienna Leacock as Trini Mumford, Molly’s best friend (besides Tooey). She moved from Texas to Qyah. •
Jules Arita Koostachin as Layla Mabray, Molly's mother • Ronnie Dean Harris as Walter Mabray, Molly's father •
Lorne Cardinal as Grandpa Nat • Adeline Potts as Auntie Midge •
Ellen Kennedy as Singing Moose, Video Voice, and Connie • Luc Roderique as Daniel, Announcer, and Cowboy on TV •
Michelle Thrush as Shyahtsoo, Aunt Merna, and Grace • Shawn Youngchief as William Patak, Maurice, Finnegan King, and Olin Benedict • Katrina Salisbury (first, second & third series) and Lauren Jackson (
The Jokulhlaup Is On Us-present) as Nina • Rhonda Rees as Barb • Pamela Jones as Sadie Albert • Nyla Carpentier as Atsaq, Tooey's mother • Taran Kootenhayoo as Randall, Molly's cousin • Pawaken Koostachin-Chakasim (first series), Sigmund Couillard (second and third series) and Michael Podemski-Bedard (fourth series onwards) as Oscar • Cynthia De Pando as Lucia • Damon Sky Taylor as Ben • Hyuma Frankowski as Kenji, Tooey's father • Tai Grauman as Mrs. Marsh, the teacher • Anna Dickey as Vera • Brendan Sunderland as Jake • Clay St. Thomas as Travis and Mr. Rowley •
Rebecca Shoichet as Dr. Antigone •
Rukiya Bernard as Violetta Lawrence • Barbara Patrick as Tatiana • Macie Juiles as Nadia Merlief • Maxine Miller as Betsy Higginbottom •
Veena Sood as Dr. Amara Batra • Bethany Brown as Joy Mumford, Trini's mother • Reneltta Arluk as Dr. Begaye, Willow's Mom, and Mary •
Cathy Weseluck as Charlotte (Sassy Ladies of Saskatoon) • Laara Sadiq as Abigail (Sassy Ladies of Saskatoon) • Mary Black as Olivia (Sassy Ladies of Saskatoon) • Nanieezh Black as Marjie • Marci T. House as Trini's grandmother Voice direction by
Nicole Oliver ==Episodes==