The first section of the line between
Takadahonzan and
Shiroko was opened by the
Ise Electric Railway on 10 September 1915. The line at this period operated with
steam locomotives. This section was extended from Shiroko to
Chiyozaki on 9 January 1916, and to
Kusu on 22 December 1917. The original line also extended south, reaching
Tsu on 1 January 1917. The line continued its extension, connecting
Kuwana, Tsu, and Daijingumae (located near the
Ise Shrine, since closed) by 25 December 1930. 's subsidiary Sankyu Rapid Electric Railway opened a branch of their own line on 18 May 1930, which extended from the current
Ise-Nakagawa to
Hisai. The Ise Electric Railway entered an economic crisis around this time, and was merged into the Sankyu Rapid Electric Railway on 15 September 1936. The branch line was extended from Hisai to Tsu on 20 June 1938. Kansai Rapid Electric Railway, also a subsidiary of the Ōsaka Electric Tram, opened the section from Kuwana to
Kintetsu Nagoya on 26 June 1938. On the same date,
Edobashi and Tsu were connected by the Sankyu Rapid Electric Railway, completing the Nagoya Line. The Edobashi Station became the border for the
narrow-gauge section north of Edobashi and the
standard-gauge section south of Edobashi. This border was later moved to Ise-Nakagawa, when the section between Ise-Nakagawa and Edobashi was narrowed to narrow-gauge in December of the same year. With the merger of the Ōsaka Electric Tram and the Sankyu Rapid Electric Railway into the Kansai Rapid Railway in March 1941, and their incorporation into the
Kintetsu Railway on 1 June 1944, the line came under Kintetsu ownership. For a brief period, the Nagoya Line was connected with the
Meitetsu Nagoya Main Line. The Kintetsu Nagoya Station was linked with the adjacent
Meitetsu Nagoya Station from August 1950 to September 1952. Using this connection, reserved group trains from Kintetsu were able to reach
Toyokawa Station near
Toyokawa Inari via the Meitetsu Nagoya Main Line and the JNR-operated
Iida Line. Meitetsu trains, on the other hand were able to reach Kuwana and Ise-Nakagawa. This link was disconnected due to changes in the layout of the Meitetsu Nagoya Station, and the construction of the
Meitetsu Department Store. The line before 1956 had many sharp curves in the city of
Yokkaichi, as the route connected the
Yokkaichi Station in the outskirts operated by the
Japanese National Railways (JNR), and the Suwa Station located in the middle of the city. However, the curves affected the max speed of the services on the line, such as the limited express service, and Kintetsu found little benefit in connecting the station to JNR's
Kansai Main Line, which had far less passengers compared to the Nagoya Line. The rerouting works to straighten the line were completed in September 1956, and the Suwa station, now named
Kintetsu Yokkaichi Station, was relocated to the new route. While the former Ise Electric Railway's route south beyond Edobashi were still in service around this period under Kintetsu ownership, this redundant route was closed in 1961. The line's limited express service held 69.4% of the shares for rail transport between Nagoya and Osaka around this time, but the share fell to 19% in 1966 following the operation of the
Tokaido Shinkansen in 1964. The line recovered after JNR's constant raising of fares from 1976. Limited express trains on the line began running at the maximum speed of in 1988 following the introduction of the
Urban Liner service and the
Kintetsu 21000 series.
Hinotori services commenced along with the introduction of the
Kintetsu 80000 series in 2020. ==Network and operations==