Nebraska Highway 40 begins in
Arnold at an intersection with
Nebraska Highway 92. It goes south out of Arnold into farmland and at an intersection with
Nebraska Highway 47, turns east. It continues east until
Nebraska Spur 21B, a spur road into
Callaway, then turns southeasterly. At
Oconto, Highway 40 meets
Nebraska Highway 21. It continues in a southeasterly direction through
Eddyville and
Sumner and at
Miller, meets
U.S. Highway 183. It continues southeast through
Amherst and
Riverdale and ends north of
Kearney at an intersection with
Nebraska Highway 10. Much of the alignment of Nebraska Highway 40 from Oconto southeastward to its eastern terminus lies parallel to the
Wood River. ==Major intersections==