Nebraska Highway 10 begins at the Kansas border south of Franklin. This terminus is also the northern terminus of
K-8. It continues north through farmland and after a brief turn northwest, turns north into
Franklin. In Franklin, it meets
U.S. Highway 136. It continues northward, staying on the same line until it meets
U.S. Highway 6 and
U.S. Highway 34 in
Minden. It continues north where it meets
Interstate 80 at interchange 279. From there it runs west, concurrently, with Interstate 80 to interchange 275, just east of the
Great Platte River Road Archway Monument. Highway 10 then crosses over US 30 at a grade separation with access provided by Link 10-F just to the north. It continues north past
Kearney Regional Airport before turning west where it meets
Nebraska Highway 40 north of Kearney. Here, it turns north again, goes through
Pleasanton, then meets
Nebraska Highway 2 at
Hazard. It turns northeast, then east and continues in that direction until an intersection with
Nebraska Link 82A, then turns north. It proceeds north until ending in
Loup City at an intersection with
Nebraska Highway 92 and
Nebraska Highway 58. ==Former alignment==