NY 85 begins at the north end of the
County Route 353 (CR 353; Delaware Turnpike) bridge over the Ten Mile Creek in the
hamlet of
Rensselaerville. In the center of the hamlet, NY 85 turns north at the intersection with
CR 351 (Medusa Road), NY 85 proceeds northward along Delaware Turnpike, a two-lane residential street through the town of Rensselaerville. The route soon becomes a woods road, turning east and passing the southern terminus of
CR 6. NY 85 bends northeast through Rensselaerville, crossing through valleys until Stevens Road, where it bends southeast and soon east into the town of
Westerlo. Still known as Delaware Turnpike, NY 85 continues east through the valleys past a junction with
CR 408. East of CR 408, NY 85 winds south of Onderdonk Lake, soon crossing a junction with
CR 1 (Switzkill Road). Bending northward through Westerlo, NY 85 remains a two-lane rural road, soon reaching a junction with the western terminus of
NY 143. NY 85 continues northeast from NY 143, becoming more residential as it approaches a junction with
CR 14 (Joslyn School Road). Crossing into the town of
Berne, NY 85 meets a junction with
CR 11 (Cass Hill Road) west of the hamlet of Reidsville. The route then bends northward at this junction, bypassing the hamlet and soon reaching the northern terminus of CR 11 (North Road) nearby. After CR 11, NY 85 continues northward through Berne, bending northeast into a junction with
NY 443 (Helderberg Trail). NY 443 and NY 85 become concurrent, proceeding eastward and south of Helderberg Lake as Delaware Turnpike. NY 85 and NY 443 continue winding eastward, crossing into the town of
New Scotland, crossing through the Letter-S, a hill named for a former S-bend alignment of NY 85 that is preserved in two town roads of similar names. Climbing down the hill, the routes bend southward, reaching a junction with New Scotland Road. At this junction, NY 443 continues southeast on Delaware Turnpike while NY 85 turns east on New Scotland. Still a two-lane road through New Scotland, NY 85 passes multiple residences before making a large curve to the north. The route bends northeast and enters the area of New Salem Hill, where it intersects with the eastern terminus of
NY 157 (Thacher Park Road). Continuing north, NY 85 soon bends southeast and enters the hamlet of
New Salem, where it intersects with the western terminus of
NY 85A (New Salem Road). Through New Salem, NY 85 is a two-lane residential street, soon leaving the hamlet after Mountain View Estates Road. Running northeast through New Scotland, NY 85 remains a two-lane residential street, crossing under CSX railroad tracks before reaching the hamlet of New Scotland. The route runs northeast through the hamlet, becoming a two-lane residential/commercial street and intersects with
CR 308 (New Scotland South Road). NY 85 quickly crosses the eastern terminus of NY 85A (Maple Road), bending southeast through New Scotland. Leaving the namesake hamlet, NY 85 continues southeast until reaching the town of
Bethlehem. Through Bethlehem, NY 85 reaches the hamlet of
Slingerlands, becoming a two-lane residential street and crossing the eastern terminus of
CR 306 (Font Grove Road). Passing a junction with Kenwood Avenue, NY 85 crosses through the commercial center of Slingerlands, soon turning northeast into another residential portion of Slingerlands. Near the northern end of the hamlet, the route enters a
roundabout with
NY 140 (Cherry Avenue Extension) and New Scotland Road (former NY 910E). NY 85 turns northwest at the roundabout, bending into another one with Vista Boulevard. Continuing northeast, NY 85 reaches a third roundabout with Maher Road (former NY 915L), which connects to New Scotland Road and the hamlet of Karlsfeld. After crossing another roundabout, this time with Blessing Road, NY 85 becomes a
two-lane freeway and crosses through the Normanskill section of Bethlehem, crossing over the
New York State Thruway (
I-87). Just after the overpass, NY 85 widens from a two-lane freeway to a four-lane
freeway, crossing into the city of
Albany and passing a ramp for Krumkill Road. Crossing over Buckingham Road, NY 85 interchanges with the local street, soon reaching an interchange with Cortland Street, which connects to
US 20 (Western Avenue). Almost immediately after US 20, NY 85 continues past another interchange, serving Washington Avenue and the
W. Averell Harriman State Office Building Campus. Just north of this interchange, Route 85 ends at
trumpet interchange with
I-90. ==History==