NY 443 begins at an intersection with
NY 30 in the town of
Schoharie, just north of the namesake
village. NY 443 proceeds east along a tributary of
Schoharie Creek, crossing through rural parts of
Schoharie County as a two-lane roadway. The route begins to wind eastward as it enters the
hamlet of Shutters Corners, bending southeast through the town of
Wright. After leaving the residential hamlet of Shutters Corners, NY 443 continues creekside through Wright, entering the hamlet of
Gallupville. In the residential community, NY 443 turns southward at a junction with the western terminus of
NY 146. At the Factory Street intersection, NY 443 turns eastward through Gallupville, turning southeast once again at a junction with
County Route 24 (CR 24; Knox Road). NY 443 and CR 24 parallel each other through Wright as they leave Gallupville, paralleling a nearby creek before it turns southeast along Fox Creek. After a long stretch along Fox Creek, NY 443 turns east at Freeman Hill Road, turning southeast again after Schell Road. A short distance southeast of Schell Road, NY 443 and Fox Creek cross the county line into
Albany County. Now in the town of
Knox. Now known as Helderberg Trail, NY 443 turns south into the hamlet of West Berne. In West Berne, the route turns east at a junction with
CR 9 (Bradt Hollow Road). Crossing east through West Berne, NY 443 continues along the creek, soon leaving West Berne for the town of
Berne. The route crosses
CR 1 (Switz Kill Road) and skirts the northern edge of Town of Berne Park. At the junction with the eastern terminus of CR 9 (Canaday Hill Road), NY 443 enters the hamlet of Berne, becoming the main commercial street, turning northward at a junction with Irish Hill Road. At the northern end of the north stretch, the route intersects with the western terminus of
NY 156 (Berne–Altamont Road). NY 443 continues east along Helderberg Trail through Berne, soon turning southeast through the town. At the junction with Turner Road, the route bends southward, then turns eastward once again. Continuing east through Berne, NY 443 becomes a two-lane rural roadway, reaching the hamlet of East Berne. The route passes south of Warners Lake and intersects with Thacher Park Road (
NY 910J) just south of that road's junction with
NY 157A. Bending southeast out of East Berne, NY 443 passes south of a local airstrip, bending southeast through the rural community. At the junction with
CR 303 (Pinnacle Road), NY 443 makes a short dart to the southeast and intersects with
NY 85 (Delaware Turnpike). Dropping the Helderberg Trail moniker, NY 443 and NY 85 become concurrent along Delaware Turnpike, passing south of Helderberg Lake. NY 443 and NY 85 remain a two-lane residential road, crossing into the town of
New Scotland. After passing the Letter S roads, NY 443 and NY 85 turn southeast, reaching a junction with New Scotland Road, where NY 85 turns eastward. NY 443 continues southward on Delaware Turnpike. Crossing through a wooded section of New Scotland, NY 443 soon bends southeast, reaching the northern terminus of
CR 312 (Clarksville South Road). After a short distance east, through the residential neighborhood of New Scotland, intersecting with the western terminus of
CR 301 (Tarrytown Road), which eventually becomes
NY 396 in
Bethlehem. Continuing east along Delaware Turnpike, NY 443 leaves the residential area, returning to the dense woods in New Scotland. Bending northeast through New Scotland, NY 443 crosses multiple residential roads that branch off, soon crossing into another residential area near the junction with
CR 308 (New Scotland South Road). Entering the hamlet of
Unionville, NY 443 crosses another junction with CR 308 (Feura Bush Unionville Road). NY 443 crosses under the
Selkirk Subdivision of
CSX Transportation, passing through the center of Unionville. The route bends northward and crosses into the town of Bethlehem, changing names to Delaware Avenue. Passing south of multiple housing residences, NY 443 passes an intersection with
CR 52 (Elm Avenue / Cherry Avenue). After crossing CR 52, NY 443 continues northeast along Delaware Avenue, entering the hamlet of
Delmar. Along this stretch, NY 443 is a long residential street, intersecting with the eastern terminus of
NY 140 (Kenwood Avenue) in the center of Delmar. Reaching the hamlet of Elsmere, NY 443 intersects with the northern terminus of
NY 335 (Elsmere Avenue). Near Euclid Avenue, the route begins to parallel the Normans Kill, crossing under the
New York State Thruway (
I-87) just east of the latter's exit 23. The route now enters the city of
Albany, crossing through the Delaware Avenue section of the city. A commercial and residential street, NY 443 soon intersects with
US 9W (Southern Boulevard). NY 443 and US 9W continue northeast along Delaware Avenue, running along the western edge of Lincoln Park, crossing into the Capitol Hill section of Albany. In this neighborhood, NY 443 and US 9W turn north into a junction with
US 20 (Madison Avenue). At this intersection, US 9W runs north on Lark Street, while NY 443 terminates at this intersection and the right-of-way merges into Lark Street. ==History==