Early works Nash made her professional acting debut in the 1995 comedy-drama film,
Boys on the Side starring
Whoopi Goldberg. On August 4, 2010, Nash announced that she was leaving
Clean House, and that the show would continue without her. Nash appeared on the
tenth season of ABC's
Dancing with the Stars beginning in March 2010, where she was partnered with
Louis van Amstel. On May 11, Nash and van Amstel were eliminated from the competition, taking fifth place. In 2011, she got her own reality show,
Leave It To Niecy, on
TLC, about her life with her new husband and stepson, but it was quickly cancelled. In that same year she was in a TLC wedding special. She also appeared in the films
Code Name: The Cleaner (2007),
Reno 911!: Miami (2007),
Cook Off! (2007),
Not Easily Broken (2009),
G-Force (2009), and
Trust Me (2013).
2012–present In 2012, Nash began starring opposite
Cedric the Entertainer in the
TV Land sitcom
The Soul Man, a spinoff of
Hot in Cleveland. The series ran five seasons and ended in 2016. In 2013, she began starring opposite
Laurie Metcalf in the
HBO comedy series
Getting On. She received a
Primetime Emmy Award for Outstanding Supporting Actress in a Comedy Series nomination for her role on the show in 2015 and 2016, as well as a
Critics' Choice Television Award for Best Supporting Actress in a Comedy Series in 2016. For her performance, Nash received positive critical reception, followed by more serious roles. In 2014, Nash played
Richie Jean Jackson, the wife of Dr. Sullivan Jackson, in the historical drama film
Selma, directed by
Ava DuVernay. DuVernay cast Nash after seeing her on the series
Getting On.
Selma was listed on many critics' top ten lists. Also that year, Nash joined the cast of the Fox comedy series
The Mindy Project in a recurring role as Dr. Jean Fishman, a rival of the title character. From 2015 to 2016, Nash co-starred on the Fox horror-comedy series
Scream Queens Also in 2016, she was cast in the leading role in the Fox comedy pilot
The Enforcers. The pilot, however, was not ordered to series. Nash later had a recurring role as Louise Bell in the Showtime period drama
Masters of Sex. In 2017, Nash was cast in a leading role in the TNT crime comedy-drama series
Claws, produced by
Rashida Jones, about a South Florida nail salon. Also in 2017, Nash appeared in
Mary J. Blige's music video for "
Strength of a Woman". For her dramatic turn in
Claws, Nash has received critical praise. She received a
Satellite Award for Best Actress – Television Series Musical or Comedy, as well as another nomination for the
NAACP Image Award for Outstanding Actress in a Comedy Series. In July 2018, Nash received a star on the
Hollywood Walk of Fame in the television category. In August 2018, it was announced that Nash would star in and produce
Naked With Niecy Nash, a late-night talk show for TNT. Later that year, Ava DuVernay cast her in the
Netflix limited drama series
When They See Us. For her performance, she received critical praise and a nomination for
Primetime Emmy Award for Outstanding Lead Actress in a Limited Series or Movie. In 2020, Nash starred in Netflix drama film,
Uncorked, directed by
Prentice Penny, and had a recurring role in the Netflix comedy-drama
Never Have I Ever, created by
Mindy Kaling. Also that year, she played civil rights advocate
Florynce Kennedy in the Hulu miniseries
Mrs. America. Later in 2020, Nash signed on to host her own syndicated daytime talk show for
CBS Television Distribution. Nash reprised her role as Deputy Raineesha Williams in the seventh season of
Reno 911! which aired on
Quibi. She starred in the Lifetime movie
Stolen by My Mother: The Kamiyah Mobley Story playing Gloria Williams, her abductor. She also appeared in the 2021
Paramount+ movie
Reno 911! The Hunt for QAnon. The eighth season of the series, titled
Reno 911! Defunded, premiered on
The Roku Channel in February 2022. During
season five of
The Masked Singer, Nash served as a guest host while regular series host
Nick Cannon recovered from
COVID-19. On April 28, 2021, Fox announced that it had ordered a revival of ''
Don't Forget the Lyrics'' with Nash as host. It premiered on May 23, 2022. Nash guest-starred on two episodes of
The Rookie, titled "Simone" and "Enervo", which served as a backdoor pilot centered on her character and aired on April 24 and May 1, 2022. On May 13, 2022, the spinoff, titled
The Rookie: Feds, was ordered. The series premiered on September 27, 2022. In July 2022, Nash signed a first-look television deal with
Entertainment One. Also that year, she played the title character's mother in the drama film,
Beauty. In late 2022, Nash starred as Glenda Cleveland in the Netflix true-crime limited series
Dahmer – Monster: The Jeffrey Dahmer Story. She received positive reviews for her performance. She won the
Primetime Emmy Award for Outstanding Supporting Actress in a Limited or Anthology Series or Movie,
Critics' Choice Television Award for Best Supporting Actress in a Movie/Miniseries, and the
NAACP Image Award for Outstanding Actress in a Television Movie, Mini-Series or Dramatic Special. Additionally, she received nominations for the
Screen Actors Guild Award for Outstanding Performance by a Female Actor in a Miniseries or Television Movie and the
Golden Globe Award for Best Supporting Actress – Series, Miniseries or Television Film. The following year, she starred in the biographical drama film
Origin by Ava DuVernay, based on the life of
Isabel Wilkerson. It premiered at the
80th Venice International Film Festival on September 6, 2023, and began a limited theatrical release in January 2024. In June of 2023, Nash was honored as
The Hollywood Reporter's Raising Our Voices Trailblazer at the second annual Raising Our Voices luncheon. In May 2025, it was announced that Nash would be one of the grand marshals at the
L.A. Pride parade. ==Personal life==