Main cast • Georgina Walker as Jane Harper; beautiful, mysterious, bitchy and intimidating, Jane was the golden girl of the neighbourhood, the girl who had everything...or at least that is how it seemed. • Nick Schofield as Ryan Harper; Jane's older brother is handsome, but insecure. A master manipulator, Ryan has learnt how to use people to his own will, and soon begins retreating back into this as he deals with being part of a broken home. •
Sally Dexter as Dr. Natalie Harper; Birth name: Natalie Brake. Jane's mother, a G.P. Despite being very highly-strung and quite secure, Natalie's initial ability to deal with her daughter's disappearance masks her true crumbling nature. • Tim Wallers as Duncan Harper; Jane's father, subordinate to Natalie. Unlike Natalie and her friends, Duncan did not grow up in the area and feels increasingly alone as past events come back to haunt others, while he cannot understand what is going on. •
Stephanie Leonidas as Della Wells; Jane's best friend, shares her birthday. Della is blossoming into her own woman, but has always lived in the shadow of Jane, and always wanted to better understand her best friend. She has fallen in love with mysterious Josh Alexander who seems just as smitten with her, but her overprotective dad Alex is an obstacle in the way of true love. •
Lysette Anthony as Roxanne Doyle; Natalie's best friend, and Della's mother. Pregnant and prone to irrational outbursts. •
Joe McGann as Alex Wells; Roxanne's partner, he is the father of all her children but her oldest, Dennis. He has a shady past, including the fact that – in the year leading up to her disappearance – he was secretly dating Jane, his daughter's best friend. Overprotective of daughter Della and has many shady secrets he would rather keep to himself. •
Kevin Sacre as Dennis Doyle; Roxanne's eldest son. Has never fully trusted his stepdad, Alex, and is now discovering adulthood. A loser in love after being rejected by bitchy Jane Harper and catty Kate Ellis. • Dominic Rickhards as Mike Brake; Natalie's younger brother. As a schoolboy, he fell for his teacher Fiona and – when she fell pregnant – the two got married. This early marriage has masked his true feelings of homosexuality, which are only now coming out. •
Glynis Barber as Fiona Brake; Mike's wife. Close to the children of the street given her nature as their schoolteacher. •
Lesley Joseph as Rachel Culgrin; the street's resident bitch, and a schoolteacher. She makes her feelings known on every subject, particularly the lifestyle of her nephew Sam, and her colleague Fiona. •
Stuart Manning as Sam Armstrong; an up-and-coming soccer player. Sam was Jane's first boyfriend, and the father of her unborn baby, although he wasn't aware of it at the time. Even though they never went all the way, she got pregnant when they were making out and he came too soon. Sam's life, however, changed when his parents were killed and he took in his sister Lucy, brother Ben, and had to deal with the sudden involvement in his life of his Aunt Rachel. Sam also consented to let Dennis move in with him. • Daniella Isaacs as Lucy Armstrong; Sam's much younger sister. Her world is the most affected by the death of her parents, and she is struggling to understand the power struggle between Rachel and Sam. •
Gareth Hunt as Charlie Doyle; Roxanne's father, he runs the local
pub and is probably the wisest of the neighbourhood. Charlie has been married several times. •
Joe Jacobs as Jimmy Hamilton Doyle; Charlie's son by a previous marriage, Jimmy is the same age as Jane and her friends and is a wild child. •
Christianne Gadd as Donna Doyle; Charlie's current wife, Brazilian. •
Cathy Tyson as Reverend Stephanie MacKenzie; the new reverend, who moves in to take over the "Halfway House" for less advantaged teens. She has a past with Natalie, Alex and Roxanne. •
Adam Paul Harvey as Tom Brake; Fiona and Mike's son, he has never been successful with girls – even though his best (female) friend is in love with him. He also is interested in film, constantly filming events that occur. • Seb Castang as Josh Alexander; a resident of the Halfway House, Josh was seeing Jane, but after her disappearance he develops feelings for Della. Josh is gorgeous, broody and intense. He is rocked by strange visions and tortured by the thought that he might have killed Jane during one of his blackouts. He has slowly fallen in love with Della Wells but pushes her away as he is scared of hurting her. • Debbie Korley as Frankie Radcliffe; Tom's best friend. She has always had a weird attitude to sex, and her feeling that sex is a disgusting will complicate her relationship with Tom. • Sean Francis as Will Radcliffe; Frankie's father, business partner and best friend to Mike. He is a single dad, and is just starting to get back out on the dating scene – but also trying to juggle it with his life as a parent. •
Phoebe Thomas as Holly Curran; one of the most enigmatic residents, Holly lives at the Halfway House and is close with Josh. She regularly speaks her mind in regard to people she does not like. She knows about Jane and Alex's relationship. •
Julia Lee Smith as Kate Ellis; she is the only person who can match Ryan in a battle of manipulation, but her talent at this also masks her insecurity. A model, she uses her looks to get what she wants and can wrap men around her little finger without any hassle.
Recurring cast • Jai Wilson as Becky Wells; daughter of Alex and Roxanne. • Keya Wilson as Laura Wells; daughter of Alex and Roxanne. •
Bradley Walsh as Eddie 'Woody' Dexter; Danny's brother and Dennis's uncle. Woody had feelings for Natalie and returns just in time to find her marriage on the rocks. • Phoebe Sweeney as Celeste Dexter; Woody's daughter, who becomes Ryan's girlfriend. • Laurie Hagen as Francois Jardin; Jane's penpal from France who arrives in the aftermath, unaware of the tragedy that befell her, and whose letters may hold clues. •
Julie Legrand as Melanie Bradshaw; a weird nurse whose delivered Jane and Della and is supposed to deliver Roxanne's new baby. Roxanne is terrified of her and suspects that she might be the source of anonymous letters which warn Roxanne her baby is not safe. • Dan D'Souza as Django Doyle; Charlie's son, a singer in Singapore who comes to stay unexpectedly and begins to manipulate his father. • Paul Kynman as 'Malcolm Burns'; the caretaker of the halfway house and grounds, who disappears some time after Jane. His death is first pronounced a suicide, but it seems more likely that he was murdered. • Jenna Boyd as Lydia; an unattractive parking inspector whom Sam starts to date out of feelings of guilt because of Jane. • Max Anthony Foster as Ben Armstrong; Sam and Lucy's baby brother. •
Coralie Rose as Aunt Begonia; Donna's attractive sister, who falls for Jimmy, her nephew-by-marriage. •
Clarke Peters as Gabriel Huysman; a mysterious stranger who claims to be a private investigator and who questions the people around Jane. •
Shane Richie as Danny Dexter; Dennis's father, who may have been involved in Jane's disappearance. • Flip Webster as Inspector Paisley; the officer who takes over Jane's case. ==Episodes==