Bonitto was selected by the
Denver Broncos with the 64th pick in the second round of the
2022 NFL draft. The Broncos used the selection previously obtained from the
Los Angeles Rams in a trade for
Von Miller. After starting the 2023 season as a backup, Bonitto started over
Randy Gregory in the Week 4 matchup against the
Chicago Bears. He recorded 2.5 sacks and a
forced fumble that led to a scoop and score by
Jonathon Cooper in the game. Gregory was traded soon after and Bonitto was named the starter. in 2025 During the
2024 season, Bonitto became the first Broncos player to have double digit sacks since
Von Miller and
Bradley Chubb in
2018. In Week 13 on
Monday Night Football against the
Cleveland Browns, Bonitto intercepted a pass from
Jameis Winston, returning it 70 yards for his first career touchdown. Then two weeks later, Bonitto scored his second touchdown of the season on a 50-yard interception return against the
Indianapolis Colts. He finished the season with 13.5 sacks and as a result he made his first Pro Bowl appearance and made the 2nd team All-Pro. Bonitto was ranked 38th by his fellow NFL players on the
Top 100 Players of 2025, his first appearance on the list. On September 4, 2025, Bonitto signed a four-year, $106 million extension (up to $120 million if incentives are met) with the Broncos, making him the highest-paid non-quarterback in Broncos history. After recording 2.5 sacks in a Week 5 victory against the
Philadelphia Eagles, Bonitto was named AFC Defensive Player of the Week. In Week 13 against the
Washington Commanders, Bonitto swatted away
Marcus Mariota's two-point conversion pass attempt in overtime, which would've won Washington the game, to seal a 27–26 Broncos overtime victory. ==NFL career statistics==