Stuttgart Born in
Stuttgart, Vlachodimos started his football career at VfL Wangen before joining
VfB Stuttgart's youth system at the age of seven. Having progressed through the clubs' youth ranks, he then made his debut for
VfB Stuttgart II on 25 February 2012 in a 1–0 loss to
1. FC Heidenheim in
3. Liga. At the end of the season, he signed his first professional contract with the club, penning a deal until June 2015. Two years later, he extended his contract with VfB until June 2017. Having made over 50 appearances for VfB Stuttgart II, Vlachodimos was afforded his
Bundesliga debut against
Eintracht Frankfurt on 29 August 2015. With back-up 'keeper
Mitchell Langerak out injured, Vlachodimos was included in Stuttgart's match day squad and was brought on as a
substitute following the
sending off of first-choice goalkeeper
Przemysław Tytoń. He made three appearances in total for the senior side but by the end of 2015 had fallen out of favour of new club
manager, and former VfB Stuttgart II coach,
Jürgen Kramny. Vlachodimos voiced his disapproval of the situation in an interview with German news publication
Kicker in December and the following month joined Greek
Super League side
Panathinaikos where he was reunited with his brother,
Panagiotis, who had joined the club earlier in the month.
Panathinaikos On 26 January 2016, Stuttgart announced that Vlachodimos had completed a
transfer to Panathinaikos. As part of the transfer, the full value of which remained undisclosed, it was agreed that Stuttgart would retain a 30% sell-on clause on Vlachodimos. He was handed his debut for the club on 3 April by manager
Andrea Stramaccioni, and started in a 3–2 home win against
Veria in the league. Having spent the majority of the first half of the following season behind regular keeper
Luke Steele, Vlachodimos was handed his second start on 27 November and was named
man of the match for his performance in a 1–1 draw against
Panionios. He started again the following week and kept his first
clean sheet for the club in a 1–0 win over
PAOK. On 17 May, Vlachodimos was
sent off in a play-off match against the same opposition for a spot in the following season's
Champions League. PAOK's
Amr Warda was dismissed minutes later before a brawl in the second half saw two more players sent off. During the incident, PAOK manager
Vladimir Ivić was struck by a beer can thrown from the Panathinaikos crowd and required treatment, ultimately resulting in the match being abandoned.
Benfica On 18 May 2018, Vlachodimos signed a five-year contract with Portuguese side
Benfica. After he arrived in
Lisbon, teammate
Bruno Varela seemed to be the first-choice goalkeeper for the
2018–19 season, but Vlachodimos' overall performance in the pre-season convinced manager
Rui Vitória to promote him to the starting spot. That season, Vlachodimos was included in
UEFA's
Champions League breakthrough team of 2018 for making a "string of impressive saves" and being "one of Benfica's brightest sparks in a testing
group stage campaign". On 3 February 2019, after 20 consecutive appearances with the club in
Primeira Liga, he faced a red card as the last player for a foul committed to
Bas Dost in a 4–2 away win over
Lisbon rivals Sporting CP. Two weeks later, in the first leg of the
UEFA Europa League round of 32 match against
Galatasaray, Vlachodimos made a crucial save in the 85th minute to deny
Christian Luyindama the equaliser, helping Benfica secure their first win in Turkey (2–1). He was elected
Primeira Liga's Goalkeeper of the Month for February. During that month, he competed in four league matches, conceding two goals as Benfica defeated Sporting,
Nacional (10–0),
Aves (3–0) and
Chaves (4–0). Moreover, he also helped his team eliminate Galatasaray 2–1 on aggregate in
UEFA Europa League's Round of 32. Vlachodimos started the
2019–20 season again as a first-choice. On 29 August 2019, he extended his contract with Benfica until 2023, setting an annual salary of €1.2 million. On 5 November 2019, Vlachodimos has been at his best in the Portuguese Primeira Liga for Benfica, recording eight clean sheets in the opening 10 matches of the season. Overall, if we take all competitions during 2019 into account, Vlachodimos participated in 46 matches for Benfica, recording 21 clean sheets. Only
Jan Oblak (24) and
Marco Bizot (29) gained more shutouts, while
Marc-André ter Stegen also tallied 24 clean sheets. On 5 October 2020, with the save of two consecutive penalty kicks from
Ryan Gauld helped his team prevail over
Farense with a score of 3–2, achieving the third victory in an equal number of matches in the beginning of the
2020–21 season. As a conclusion this
season was a reality check for the 27-year-old as he played as a second fiddle to
Helton Leite for most of the campaign. He has, however, regained his form and put up some excellent displays in the
2021–22 season. On 26 August 2021, Benfica qualified for the
UEFA Champions League group stage after defeating
PSV Eindhoven, a justification for the international Greek goalkeeper who in the summer was a step away from "Da Luz". On 4 November 2021, although he conceded five goals in the 5–2 defeat to
Bayern Munich, Pathodimos is included in the top 11 of the 4th matchday in the
UEFA Champions League. On beginning of December 2021,
Newcastle United are reportedly interested in signing highly coveted Vlachodimos. According to the Portuguese outlet
O Jogo, Benfica could be battling to keep hold of their star goalkeeper with Newcastle United eyeing a January swoop for the Greek international. The Magpies have identified the 27-year-old as a top target and want to open discussions with the Portuguese giants in the coming weeks ahead of the January transfer window. On 26 January 2022, the Portuguese press praised Vlachodimos for his performance in the victory of Benfica over
Boavista in the
2021–22 Taça da Liga final, where the Greek goalkeeper was voted
man of the match. Benfica were led to the penalty shootout with Boavista (1–1 in the regular game), where they prevailed 3–2, with the 27-year-old goalkeeper repelling three of the five penalties. In fact, this was the first participation of the Greek international in the tournament, while he is in Portugal, while he reached a total of 150 appearances with the Benfica jersey. On 8 March 2023, the Greek goalkeeper signed a contract that runs until the summer of 2027, with the Portuguese "A Bola" reporting that the agreement between the two sides also includes a release clause of €60 million.
Nottingham Forest On 31 August 2023, Vlachodimos signed with
Premier League side
Nottingham Forest on a four-year contract, for a fee of €4.9 million, with the potential to rise to €9.3 million with add-ons. Vlachodimos made his Premier League debut on 5 November 2023 against
Aston Villa keeping a clean sheet in a 2–0 win.
Newcastle United On 1 July 2024, Vlachodimos joined fellow Premier League club
Newcastle United. He was signed for a fee of £20 million which is the most Newcastle have paid for a goalkeeper. He made his Newcastle United debut on 1 October 2024, replacing the injured
Martin Dúbravka at half time in their 1–0 victory over
AFC Wimbledon in the
EFL Cup.
Loan to Sevilla On 12 August 2025, Vlachodimos was loaned to
La Liga side
Sevilla for one year. ==International career==