(),
ginseng,
Luo Han Guo, turtle shell underbelly (
plastron), and dried curled snakes. in a "crush cage" on Huizhou Farm, China s are extensively used in traditional medicine in China and elsewhere. Thus, the term "medicinal" (instead of herb) may be used. A 2019 review of traditional herbal treatments found they are widely used but lacking in scientific evidence, and urged a more rigorous approach by which genuinely useful medicinals might be identified. Plant elements and extracts are by far the most common elements used. In the classic
Handbook of Traditional Drugs from 1941, 517 drugs were listed – out of these, 45 were animal parts, and 30 were minerals. hornet nests,
leeches, and
scorpion. Other examples of animal parts include horn of the antelope or buffalo, deer antlers, testicles and
penis bone of the dog, and snake bile. Some compounds can include the parts of endangered species, including tiger bones and
rhinoceros horn which is used for many ailments (though not as an aphrodisiac as is commonly misunderstood in the West). The black market in rhinoceros horns (driven not just by TCM but also unrelated status-seeking) has reduced the world's rhino population by more than 90 percent over the past 40 years. Concerns have also arisen over the use of
pangolin scales, turtle
plastron, seahorses, and the
gill plates of
mobula and
manta rays. Poachers hunt restricted or endangered species to supply the black market with TCM products. There is no scientific evidence of efficacy for tiger medicines. Since TCM recognizes
bear bile as a treatment compound, more than 12,000
asiatic black bears are held in bear farms. The bile is extracted through a permanent hole in the abdomen leading to the
gall bladder, which can cause severe pain. This can lead to bears trying to kill themselves. As of 2012, approximately 10,000 bears are farmed in China for their bile. As of March 2020 bear bile as ingredient of
Tan Re Qing injection remains on the list of remedies recommended for treatment of "severe cases" of COVID-19 by National Health Commission of China and the National Administration of Traditional Chinese Medicine. The
deer penis is believed to have therapeutic benefits according to traditional Chinese medicine. Tiger parts from poached animals include
tiger penis, believed to improve virility, and tiger eyes. The illegal trade for tiger parts in China has driven the species to near-extinction because of its popularity in traditional medicine.
Shark fin soup is traditionally regarded in Chinese medicine as beneficial for health in East Asia, and its status as an elite dish has led to huge demand with the increase of affluence in China, devastating shark populations. The shark fins have been a part of traditional Chinese medicine for centuries. Shark finning is banned in many countries, but the trade is thriving in Hong Kong and China, where the fins are part of shark fin soup, a dish considered a delicacy, and used in some types of traditional Chinese medicine. The
tortoise (
freshwater turtle,
guiban) and turtle (
Chinese softshell turtle,
biejia) species used in traditional Chinese medicine are raised on farms, while restrictions are made on the accumulation and export of other endangered species. However, issues concerning the
overexploitation of Asian turtles in China have not been completely solved. Finally, although not an endangered species, sharp rises in exports of donkeys and donkey hide from Africa to China to make the traditional remedy
ejiao have prompted export restrictions by some African countries.
Human body parts (Ziheche () is used in traditional Chinese medicine. Human placenta has been used an ingredient in certain traditional Chinese medicines, including using dried human placenta, known as "Ziheche", to treat infertility, impotence and other conditions. The consumption of the human placenta is a potential source of infection.
Efficacy there were not enough good-quality trials of herbal therapies to allow their effectiveness to be determined. A high percentage of relevant studies on traditional Chinese medicine are in Chinese databases. Fifty percent of systematic reviews on TCM did not search Chinese databases, which could lead to a bias in the results. Many systematic reviews of TCM interventions published in Chinese journals are incomplete, some contained errors or were misleading. The herbs recommended by traditional Chinese practitioners in the US are unregulated. • A 2013 review found the data too weak to support use of Chinese herbal medicine (CHM) for
benign prostatic hyperplasia. • A 2013 review found the research on the benefit and safety of CHM for idiopathic sudden sensorineural hearing loss is of poor quality and cannot be relied upon to support their use. • A 2013
Cochrane review found inconclusive evidence that CHM reduces the severity of eczema. • The traditional medicine ginger, which has shown anti-inflammatory properties in laboratory experiments, has been used to treat
rheumatism, headache and digestive and respiratory issues, though there is no firm evidence supporting these uses. • A 2012 Cochrane review found no difference in
mortality rate among 640 SARS patients when Chinese herbs were used alongside Western medicine versus Western medicine exclusively, although they concluded some herbs may have improved symptoms and decreased corticosteroid doses. • A 2012 Cochrane review found insufficient evidence to support the use of TCM for people with adhesive small bowel obstruction. • A 2011 review found low quality evidence that suggests CHM improves the symptoms of
Sjögren's syndrome. • A 2011 Cochrane review found inconclusive evidence to support the use of TCM herbal medicines for treatment of
hypercholesterolemia. • A 2011 Cochrane review did not find improvement in fasting
C-peptide when compared to
insulin treatment for
latent autoimmune diabetes in adults after 3 months. It is important to highlight that the studies available to be included in this review presented considerable flaws in quality and design. • A 2010 review found TCM seems to be effective for the treatment of fibromyalgia but the findings were of insufficient methodological rigor. • A 2008 Cochrane review found promising evidence for the use of Chinese herbal medicine in relieving
painful menstruation, but the trials assessed were of such low methodological quality that no conclusion could be drawn about the remedies' suitability as a recommendable treatment option. •
Turmeric has been used in traditional Chinese medicine for centuries to treat various conditions. This includes jaundice and hepatic disorders, rheumatism, anorexia, diabetic wounds, and menstrual complications. • A 2005 Cochrane review found insufficient evidence for the use of CHM in HIV-infected people and people with
AIDS. • A 2010 Cochrane review found insufficient evidence to support the use of Traditional Chinese Herbal Products (THCP) in the treatment of
angina. • A 2010 Cochrane review found no evidence supporting the use of TCHM for stopping bleeding from
haemorrhoids. There was some weak evidence of pain relief.
Drug research '', traditionally used to treat fever, has been found to have
antimalarial properties. There was success in the 1970s, however, with the development of the antimalarial drug
artemisinin, which is a chemical compound isolated the herb
Artemisia annua that has been used traditionally as a treatment for fever.
Artemisia annua has been used by Chinese herbalists in traditional Chinese medicines for 2,000 years. In 1596, Li Shizhen recommended tea made from qinghao specifically to treat malaria symptoms in his
Compendium of Materia Medica. Researcher
Tu Youyou discovered that a low-temperature extraction process could isolate an effective antimalarial substance from the plant. The extracted substance, once subject to detoxification and purification processes, is a usable antimalarial drug For her work on malaria, Tu received the 2015
Nobel Prize in Physiology or Medicine. Despite global efforts in combating malaria, it remains a large burden for the population. Also in the 1970s Chinese researcher
Zhang TingDong and colleagues investigated the potential use of the traditionally used substance
arsenic trioxide to treat
acute promyelocytic leukemia (APL). Building on his work, research both in China and the West eventually led to the development of the drug
Trisenox, which was approved for leukemia treatment by the FDA in 2000.
Huperzine A, an extract from the herb,
Huperzia serrata, is under preliminary research as a possible therapeutic for Alzheimer's disease, but poor methodological quality of the research restricts conclusions about its effectiveness.
Ephedrine in its natural form, known as
má huáng () in TCM, has been documented in China since the
Han dynasty (206 BCE – 220 CE) as an
antiasthmatic and stimulant. In 1885, the chemical synthesis of ephedrine was first accomplished by Japanese
organic chemist Nagai Nagayoshi based on his research on
Japanese and Chinese traditional herbal medicines
Pien tze huang was first documented in the
Ming dynasty.
Cost-effectiveness A 2012 systematic review found there is a lack of available
cost-effectiveness evidence in TCM.
Safety From the earliest records regarding the use of compounds to today, the toxicity of certain substances has been described in all Chinese materiae medicae. For most compounds, efficacy and toxicity testing are based on traditional knowledge rather than laboratory analysis. The toxicity in some cases could be confirmed by modern research (i.e., in scorpion); in some cases it could not (i.e., in
Curculigo). Botanical misidentification of plants can cause toxic reactions in humans. Traditional herbal medicines are sometimes contaminated with toxic heavy metals, including lead, arsenic, mercury and cadmium, which inflict serious health risks to consumers. Also, adulteration of some herbal medicine preparations with conventional drugs which may cause serious adverse effects, such as
corticosteroids,
phenylbutazone,
phenytoin, and
glibenclamide, has been reported. Substances known to be potentially dangerous include
Aconitum, the Chinese beetle (
Mylabris phalerata), certain fungi,
Aristolochia (which is known to cause cancer). and
cinnabar. Asbestos ore (
Actinolite, Yang Qi Shi, 阳起石) is used to treat impotence in TCM. Due to
galena's (
litharge,
lead(II) oxide) high lead content, it is known to be toxic. Lead, mercury, arsenic, copper, cadmium, and thallium have been detected in TCM products sold in the U.S. and China. To avoid its toxic adverse effects
Xanthium sibiricum must be processed. A 2013 review suggested that although the
antimalarial herb
Artemisia annua may not cause hepatotoxicity, haematotoxicity, or hyperlipidemia, it should be used cautiously during pregnancy due to a potential risk of embryotoxicity at a high dose. However, many adverse reactions are due to misuse or abuse of Chinese medicine. The harvesting of
guano from bat caves (
yemingsha) brings workers into close contact with these animals, increasing the risk of
zoonosis. The Chinese virologist
Shi Zhengli has identified dozens of SARS-like
coronaviruses in samples of bat droppings. ==Acupuncture and moxibustion==