The use of drugs like mephedrone, GHB/GBL, and crystal meth before or during sex, can have physical effects. These can include dehydration, a higher risk of HIV and other sexually transmitted infections (STIs), and drug-related injuries. Dehydration is a widespread problem with chemsex. This can lead to serious health problems, including seizures and even death. GHB/GBL and crystal meth can also increase the risk of injuries due to accidents or sexual encounters that go wrong. These injuries can be as minor as cuts and bruises, but they can also be dangerous in severe cases, such as haemorrhages, anal fissures, ripped anuses, anal prolapse and suffocation. Furthermore, the use of these drugs can affect erection and ejaculation. Gay/Bisexual men will often use Viagra or other ED drugs to overcome this issue. Unfortunately, this means that their body has to cope with drug interactions that can go wrong leading, in some cases, to overdose, seizures, drug induced heart attacks, stroke, paralysis, neurological damage and even death. These physical risks are higher in older men and those with pre-existing medical conditions. The same drug-induced loss of inhibitions makes PNP enthusiasts more vulnerable to more immediate threats, such as
robbery,
date rape,
assault, or
murder, by someone whom they meet for sex. Men in the chemsex scene have stated that
sexual consent is not clearly defined and there can be a perception that anyone at a "party and play" get-together is assumed to consent. Some substances like GHB and ketamine can cause an inability to communicate or remain conscious which raises serious issues of consent. Using drugs to intentionally sexually violate someone is called
Drug-Facilitated Sexual Assault. The abuse of drugs such as methamphetamine may cause neurological damage. Impaired judgement due to intoxication may lead to
bareback sex, which increases the chances of contracting HIV. Methamphetamine suppresses autonomic response and can cause sores and abrasions in the mouth. Open wounds or damaged mucous membranes can turn typically low-HIV-risk sex acts such as oral sex into much-higher-risk sexual activity unless all HIV-positive participants are undetectable on HAART, and all HIV-negative participants are taking
pre-exposure prophylaxis in strict accordance with prescription instructions. ==Statistics==