Estimates for the pre-contact populations of most Native groups in California have varied substantially.
Alfred L. Kroeber put the 1770 population of the Wintun, including the Patwin, Nomlaki, and Wintu proper, at 12,000.
Sherburne F. Cook (1976a:180-181) estimated the combined population of the Patwin and Nomlaki at 11,300, of which 3,300 represented the southern Patwin. He subsequently raised his figure for the southern Patwin to 5,000. The migration of American settlers during the Gold Rush, which began in 1848, profoundly affected the Indigenous communities in California, particularly the Patwin people. Thousands of migrants, predominantly men, flocked to California in search of wealth. This influx led to the displacement of Native communities, exposing them to diseases, violent raids, and the degradation of their environment due to resource extraction. Prior to the Gold Rush, the Patwin resided in settled villages throughout the western Sacramento Valley, engaging in traditional practices of hunting, gathering, and fishing. The arrival of Western migrants severely disrupted this way of life as settler expansion encroached on their lands. Areas crucial for acorn gathering and access to water were taken or destroyed to make way for mining, ranching, and agricultural development. Historian Sherburne F. Cooke documents a significant population decline among the Patwin during this period, primarily attributed to disease outbreaks such as smallpox and measles. The indirect effects of colonization and displacement further exacerbated this decline. The Patwin were also compelled to perform unpaid labor in various settings, from domestic residences to mining operations, a practice that has been described as a form of “the other slavery.” By the late 1850s, the Patwin population had dwindled to a mere fraction of its pre-contact numbers, mirroring the widespread decline experienced by Indigenous tribes in California throughout the Gold Rush era. Kroeber estimated the population of the combined Wintun groups in 1910 as 1,000. By the 1920s, no Patwin remained along Putah Creek and few were left in the area. Today, Wintun descendants of the three groups (i.e. the Patwin, Nomlaki, and Wintu proper) total about 2,500 people. ==Villages==