Atlético Madrid (2004–2010) After developing with the youth teams of
Atlético Madrid, Hermoso made her senior team debut in the
Segunda División on 5 December 2004, at age 14. In her first match, she scored a goal in a 6–0 victory over Vicálvaro. During the 2005–06 season, she played 16 games and scored 12 goals, including a goal against
UE L'Estartit that secured Atlético's promotion to the
Superliga. After eight years of playing with the club, Hermoso left in 2010. Rayo, which won the
2009–10 Superliga, were automatically qualified to the
2010–11 UEFA Women's Champions League Round of 32. Hermoso scored her first Champions League goals against
Icelandic club
Valur. Rayo reached the knockout stages, where they were eliminated by
Arsenal. In the
final of the
2010–11 Superliga, Rayo Vallecano played
RCD Espanyol in a two-legged tie. In the first leg, Hermoso scored a penalty kick which gave Rayo the lead before Espanyol equalised the score. Hermoso went on to score the tie-winning goal in the return leg, winning her first ever league title and Rayo's third. In
qualification for the
2011–12 UEFA Women's Champions League, Hermoso scored two goals against
Estonian club
Pärnu. In the final match of qualifying, Hermoso scored her first Champions League
hat-trick against
Slovenian team
ŽNK Krka. Rayo finished the qualification round with 3 wins from 3 matches to advance to the Round of 32 of the Champions League, where Hermoso scored her first Champions League knockout round goal against Valur. Rayo was eliminated in the Round of 16, again against
Arsenal. Hermoso left Rayo in 2013 during the Nueva Rumasa scandal that left Rayo's women's team without financial support.
Tyresö FF (2013) in 2013 After leaving Rayo Vallecano, Hermoso signed with the Swedish club
Tyresö FF for the
2013 season. The move to Sweden was Hermoso's first time playing football outside of Spain. Hermoso debuted with Tyresö in the
Champions League on 9 October against
Paris Saint-Germain (PSG). She then played two other Champions League matches with the club, one against PSG and another against
Fortuna Hjørring. Hermoso left the club in December after scoring 6 goals in 20 league matches. Tyresö would end up being runners-up in the
Damallsvenskan and runners-up in the Champions League.
FC Barcelona (2014–2017) 2013–14 season At the end of the 2013 Damallsvenskan season, Hermoso contacted then-coach
Xavi Llorens about playing for
FC Barcelona Femení. In January 2014, she joined Barcelona on a 6-month contract. On 12 April 2014, Hermoso scored Barcelona's third and final goal in a match against
Atlético Madrid, which clinched the club's third league title. On 21 June, Hermoso started the
2014 Copa de la Reina final against
Athletic Club Femenino, which went to a
penalty shootout after being tied 1–1 in
extra time. Hermoso scored her penalty kick and won her first
Copa de la Reina trophy.
2014–15 season Hermoso was
cup-tied with
Tyresö for the
2013–14 UEFA Women's Champions League season, and was unable to make her debut with Barcelona in the competition until the
2014–15 season. On 22 April 2015, Hermoso won her second Spanish league title with Barcelona and her third overall.
2015–16 season In her second full season at the club, Hermoso moved farther up the pitch to play as a
false 9. In her new position, she began to develop into a prolific goalscorer. She scored her first Champions League goal for Barcelona against the
Kazakh team
BIIK Kazygurt. In the
2016 Copa de la Reina final against
Atlético Madrid, Hermoso scored two goals as Barcelona was defeated 3–2. At the end of the league season, Hermoso earned her first
Pichichi title after scoring 24 goals.
2016–17 season In February 2017, Hermoso was nominated to the 2016
FIFPro Women's World 11 for the first time. She was selected as 9th among the 15 players in the midfielder category. In March 2017, Hermoso scored a header against
FC Rosengård in the quarter-finals of the
2016–17 UEFA Women's Champions League to help send Barcelona to their first ever Champions League semi-final. On 2 May, she scored 6 goals in a 13–0 win over the
Basque club
Oiartzun. Hermoso finished as the top league scorer for the second season in a row, with 35 goals in 27 matches. In the
2017 Copa de la Reina final in June, Hermoso scored twice to win her second Copa de la Reina title with Barcelona. Hermoso scored a total of 77 goals in 90 games during her first 3-year stint at Barcelona.
Paris Saint-Germain (2017–2018) On 3 July 2017, Hermoso signed a three-year contract with
Paris Saint-Germain (PSG). At PSG, she played more as a
midfielder than as a
forward under coach
Patrice Lair. She debuted with the team on 10 September in a 3–0 win over
Rodez, and scored her first goal on 17 December. With PSG she played 19 of the 22 league games and scored 6 goals. She was the team's leader in assists, with seven. Atlético was the runner-up in the
2018–19 Copa de la Reina. Hermoso was named the ninth-best playmaker of 2018 by the
International Federation of Football History & Statistics (IFFHS) and the best Spanish player of 2018 by
The Guardian. She was named to the league's Best XI of the season.
FC Barcelona (2019–2022) 2019–20 season Hermoso returned to
FC Barcelona after two seasons away, signing a three-year contract in July 2019. In her first match back on 6 September, she scored a
hat-trick within 18 minutes against CD Tacón (now known as
Real Madrid Femenino). On 1 March 2020, Hermoso scored her 100th league goal with Barcelona with a hat-trick against
Madrid CFF. By May, the
COVID-19 pandemic had resulted in the cancellation of the
2019–20 league season, and Barcelona was crowned the winner with 21 matchdays remaining. Hermoso finished as the league's top scorer with 23 goals, as well as the top scorer in Europe's top five leagues. When the
2019–20 UEFA Women's Champions League resumed in August, she competed in Barcelona's remaining matches as her club was eliminated in the
semi-finals against
VfL Wolfsburg. At the end of the campaign, Hermoso was named to the
UEFA Women's Champions League Squad of the Season for the first time. Due to the pandemic, the
2019–20 Copa de la Reina was postponed until it could be played during the 2020–21 season. Hermoso played the final of the 2019–20 Copa de la Reina on 13 February 2021, where she scored Barcelona's third and final goal against
EdF Logroño. It was her third Copa de la Reina title with the club.
2020–21 season On 5 December 2020, Hermoso recorded four goals in one league match against
Santa Teresa CD, scoring her 124th goal with Barcelona and surpassing
Sonia Bermúdez as FC Barcelona Femeni's all-time top scorer. She then overtook Bermúdez's record number of 108 league goals scored with Barcelona. At the end of 2020, Hermoso was nominated for
FIFA's The Best award, alongside teammate
Caroline Graham Hansen. She was also one of eight FCB Femení players nominated for UEFA Women's Team of the Year. Hermoso became the first Spanish player and the first player from the Spanish league to be recognized as the
top scorer in the UEFA Women's Champions League; with six goals, she was tied with
Fran Kirby. She was also named to the UEFA Women's Champions League
Squad of the Season for the second time. Later in the year, Hermoso won the UEFA Women's Champions League
Forwards of the Season award. During the 2020–21 season, Hermoso competed with
Levante's
Esther González to be the league's top scorer. Their race for the
Pichichi trophy continued until the final matchday of the league. Hermoso, who had 28 goals to González's 29, scored a hat-trick against
Eibar to earn her third consecutive Pichichi title and fifth overall, surpassing
Sonia Bermúdez for the most Pichichi titles. Hermoso ended her season with 31 league goals and finished as the top scorer in
Europe's top five leagues for the second consecutive season. In August 2021, she was a finalist for the
UEFA Women's Player of the Year Award alongside Barcelona teammates
Alexia Putellas and
Lieke Martens.
2021–22 season At the beginning of the 2021–22 season, Hermoso regained her number 10 shirt number upon the departure of
Kheira Hamraoui. She played in her club's first ever
Gamper Trophy match against
Juventus; she scored two goals and was Player of the Match. In November, she finished second in
Ballon d'Or voting behind teammate
Alexia Putellas. Hermoso finished the 2021 calendar year with 51 goals in all competitions, the most of any female footballer in the world.
Pachuca (2022–2023) After weeks of speculation about her future, Hermoso signed with Mexican club
Pachuca of
Liga MX Femenil on 21 June 2022. She scored 18 goals in the regular season of
Clausura 2023, making her the second-highest scorer behind her teammate
Charlyn Corral. Hermoso's three goals in the playoffs made her and
Corral the joint top scorers with 21 goals over the full Clausura.
Tigres UANL (2024–2026) On 1 January 2024, Hermoso signed with the Mexican club
Tigres UANL. ==International career==