PA 52 begins at the
Delaware border in
Pennsbury Township,
Chester County, at which point the road continues south into Delaware as
DE 52. From the state line, the route heads north-northwest on two-lane undivided Kennett Pike through wooded residential areas. The road enters
Kennett Township and heads northwest to the community of
Mendenhall, where it crosses an
East Penn Railroad line at-grade. Farther northwest, PA 52 comes to an intersection with
US 1 (
Baltimore Pike) in the community of
Hamorton and turns west to form a
concurrency with that route, which is a four-lane
divided highway that passes fields. Near
Longwood Gardens, PA 52 splits from US 1 by heading north on two-lane undivided Lenape Road. The road runs a short distance east of the border between
East Marlborough Township to the west and Pennsbury Township to the east as it passes through a mix of woods and fields, intersecting
PA 926 (Street Road). Past this intersection, the road passes through forested residential areas, crossing into
Pocopson Township as it winds more to the northeast and reaches a
roundabout with Lenape Unionville Road and South Wawaset Road. In the community of
Lenape, PA 52 heads across another East Penn Railroad line at-grade prior to crossing the
Brandywine Creek and then over a parking lot on the
Lenape Bridge into
Birmingham Township. Here, the road turns northwest onto Creek Road (the old alignment of
PA 100) prior to continuing northeast along Lenape Road into
East Bradford Township. The route passes through areas of woods, fields, and housing developments prior to intersecting West Rosedale Avenue. At this point, PA 52 heads northwest on Bradford Avenue, forming the border between East Bradford Township to the west and the borough of
West Chester to the east, passing homes. The route makes a turn northeast onto Price Street, fully entering West Chester, where it continues through residential areas. The route comes to its northern terminus at
US 322 Bus. (South High Street) a short distance north of the
West Chester University campus. At this intersection, the old alignment of PA 100 turned north onto South High Street. ==History==