US 322 Bus. begins at an intersection with
US 322 northwest of the borough of
West Chester in
East Bradford Township,
Chester County, heading southeast on Downingtown Pike. From this point, Downingtown Pike continues northwest as US 322 towards the borough of
Downingtown. From the western terminus, the route is a three-lane undivided road with one eastbound lane and two westbound lanes. The road soon becomes a three-lane road with a
center left-turn lane as it passes through a mix of woodland and businesses. US 322 Bus. crosses into the borough of West Chester and comes to an intersection with the eastern terminus of
PA 162 before the name changes to Hannum Avenue. The route curves east past homes and businesses before it splits into a
one-way pair. Eastbound US 322 Bus. heads southeast on North New Street and northeast on West Market Street while westbound US 322 Bus. follows West Chestnut Street. The eastbound direction has two lanes of traffic while the westbound direction has one lane of traffic. Eastbound US 322 Bus. intersects the eastern terminus of
PA 842, which comes from the west along West Market Street, at the intersection of New and Market streets. US 322 Bus. follows Market and Chestnut streets northeast through the commercial downtown of West Chester. West Market Street passes between the Chester County Justice Center to the north and
SEPTA's
West Chester Transportation Center and a parking garage to the south between New and Darlington streets. Upon reaching High Street, US 322 Bus. turns southeast onto that street, with East Market and East Chestnut streets continuing east as
PA 3. At the northwest corner of High and Market streets is the historic
Chester County Courthouse. US 322 Bus. follows two-lane undivided South High Street southeast through more of the downtown and intersects the beginning of westbound PA 842, which follows West Miner Street. The route leaves the downtown area and continues past a mix of homes and businesses. The road intersects the northern terminus of
PA 52 at Price Street and runs southeast through the
West Chester University campus. At the Rosedale Avenue intersection, US 322 Bus. leaves West Chester for
West Goshen Township and becomes a three-lane road with a center left-turn lane that passes homes to the west and the university to the east. The route curves south into wooded neighborhoods and loses the center turn lane. US 322 Bus. widens to four lanes and passes businesses before it comes to its eastern terminus at an interchange with
US 202/US 322 at the southern terminus of the
freeway bypass of West Chester. South of here, the road continues south as US 202/US 322, called the Wilmington Pike. ==History==