Mononyms •
Pepe (footballer, born 1935), Brazilian footballer José Macia •
Pepe (footballer, born February 1983), Brazilian-born Portuguese footballer Képler Laveran Lima Ferreira •
Pepe (footballer, born October 1983), Brazilian footballer Marcos Paulo Aguiar de Jesus •
Pepê (footballer, born 1997), Brazilian footballer Eduardo Gabriel Aquino Cossa •
Pepê (footballer, born 1998), Brazilian footballer João Pedro Vilardi Pinto
Politicians •
Porfirio Lobo Sosa (born 1947), known as Pepe, candidate for the Presidency of Honduras •
José Mujica (1935–2025), known as El Pepe, president of Uruguay •
José Gregorio Liendo (1945–1973), known as "comandante Pepe," "compañero Pepe," or "loco Pepe," Chilean political activist •
José W. Diokno (1922–1987), known as "Ka Pepe," Filipino nationalist and senator •
José Rizal (1861–1896), Filipino nationalist who used the name with his family
Musicians •
Pepe Romero (born 1944), Spanish classical and flamenco guitarist •
Pepe Aguilar (born 1968), American folklore singer •
Pépé Kallé (1951–1998), Congolese Soukous singer •
Pepe Smith (1947–2019), real name Joseph William Feliciano Smith, Filipino rock singer and drummer
Sportsmen •
Pepe Frías (born 1948), Puerto Rican MLB player •
Pepe Oriola (born 1994), Spanish racing driver •
Pepe Pearson (born 1975), American football player •
Pepe Reina (born 1982), Spanish footballer •
Pepe Sánchez (basketball) (born 1977), Argentine basketball player •
Pepe Soares (1908–1931), Portuguese footballer
Actors •
Pepe Herrera (born 1987), Filipino actor, singer, and comedian
Artists •
Pepe Soho (1971–2025), Mexican landscape and nature photographer
Surname •
Anna Pepe (born 2003), known professionally as Anna, Italian rapper and singer-songwriter •
Cécé Pepe (born 1996), French footballer •
Florestano Pepe (1778–1851), Italian soldier, brother of Guglielmo •
Gabriele Pepe (1779–1849), Italian soldier, cousin of Guglielmo •
Guglielmo Pepe (1783–1855), Italian general •
Nico Pepe (1917–1987), Italian actor •
Nicolas Pépé (born 1995), French-Ivorian footballer •
Osman Pepe (born 1954), Turkish politician •
Simone Pepe (born 1983), Italian footballer •
Vincenzo Pepe (born 1987), Italian footballer ==Fictional characters==