The
type specimen were collected at near
Huacachi, Peru at an altitude of 1950 meters above sea level.
Peperomia macbrideana is a rather large, ascending herb with a somewhat thick
stem, 3–6 mm in diameter, with short, glabrate internodes. The
leaves are alternate or occasionally subopposite, round-elliptic to orbicular, rounded at both ends, and medium-sized, measuring 4–6 cm long and 3.5–5 cm wide. They are palmately
5-nerved, with branched nerves, and have rust-colored villous hairs on the underside along the nerves. The slender
petiole is 3–8 cm long, shorter on the upper leaves. The
spikes are congested in a spicate arrangement at the apex of a pilose branchlet. When young, they are barely 5 mm long. ==Taxonomy and naming==