Prostaglandin D2

• Cellular synthesis occurs through the arachidonic acid cascade with the final conversion from PGH2 done by PGD2 synthase (PTGDS). • In the brain, production occurs via an alternative pathway through the soluble, secreted enzyme β-trace ==Effects==

• PGD2 promotes bronchoconstriction and vasoconstriction during times of Inflammation to alert the host of danger. Its concentration in asthma patients is 10 times higher than in control patients, especially after it is brought into contact with allergens, air pollution, secondhand smoke and smoke. • PGD2 is involved in the regulation of reducing body temperature in sleep, and acts opposite to PGE2. • Elevated levels of PGD2 and PGD2 synthase in scalp hair follicles may be partially responsible for male pattern baldness. • PGD2 also plays a part in male sexual development. It forms a feedforward loop with Sox9, which is activated by the SRY of the Y chromosome. PGD2, in a different feedforward loop than FGF9, helps keep the level of SOX9 high enough to activate other genes, such as Fgf9 and Sf1, which are necessary for the development of the male reproductive system. • PGD2 plays a role in the attraction of neutrophils (chemotaxis). • PGD2-Adenosine system promotes sleep. == Inhibitors ==

In silico simulations have predicted the following as potential inhibitors of PGD2 synthase: • Acteoside • Amentoflavone • Ricinoleic acid • Rutin • Hinokiflavone • Vitamin K and Vitamin D3 are natural inhibitors of Prostaglandin synthesis. ==See also==