A special government program, training and deploying highly intelligent rodents as
secret agents, is facing abolition from the
FBI. To save the department, Dr. Ben Kendall, the head of the program, orders an unauthorized mission for the primary field team known as G-Force, consisting three
guinea pigs named Darwin, Blaster, and Juarez, a
mole named Speckles, and a
fly named Mooch. The mission is to infiltrate the residence of home electronics magnate Leonard Saber, and acquiring information about a new
microchip he has developed. Darwin finds a classified file titled Clusterstorm on Saber's personal computer, containing plans for global extermination, and downloads it to his
PDA. However, the next day, the file turns out to be false, which angers Ben's superior, Agent Kip Killian, who shuts down the program. He orders the animals' capture, forcing Darwin, Blaster, Juarez, and Speckles to escape and hide in a delivery truck that goes to a
pet store where they are mistaken for ordinary rodents and are locked up in a cage. They meet Hurley, another guinea pig, Bucky, a cocky hamster, and three mice. Determined to finish their mission, each of them forms an escaping plan. Blaster and Juarez get themselves sold to a family, while Speckles pretends to be dead to get buried, but is thrown into a garbage truck instead, seemingly crushed to death. Darwin escapes with Hurley's help, who becomes convinced that Darwin is his long-lost brother due to their birthmark. While Blaster and Juarez escape their new owners, Ben and his assistant Marcie retrieve Darwin's PDA from the FBI, and discover that it is infected with an
extermination virus. Saber holds a meeting with his associates, including his prime engineer, the mysterious "Mr. Yanshu", and reports that Clusterstorm will launch in less than 48 hours. On their way to Ben's house, Darwin and Hurley see a Saberling coffee machine and Darwin decides to investigate it. Upon trying to remove its microchip, the coffee machine turns into a violent robot, but was later destroyed. G-Force reunites at Ben's, but after hearing of what happened to Speckles, Ben reveals to the team that neither of them were genetically engineered as they believed. They were rescued from various places, and Darwin himself was bought from a pet shop just like Hurley told him earlier. Despite learning their true origins, the team still has faith in themselves. Deciding to use the infected PDA to shut down the microchips, they go to Saber's mansion in their
hamster ball-shaped vehicles, during which they escape from the FBI agents sent by Killian to capture them. At Saber's mansion, G-Force tries to reach the mainframe, but Hurley accidentally steps on a bomb-trap, resulting in an explosion which separates Blaster and Juarez from Darwin. Clusterstorm activates, turning all Saberling products into killing machines around the world. When an FBI field team led by Killian arrives at Saber's mansion to arrest him, he stated that he simply wanted to use the microchips for electronic communication. Arriving in Saber's basement, Darwin discovers that a surviving Speckles is Mr. Yanshu, the mastermind behind Clusterstorm (Yanshu means "mole" in Chinese). He elaborates his plan to use the Saberling products for a bombardment of
space debris to make Earth's surface uninhabitable, therefore destroying humanity as revenge for killing his family. It is revealed that he staged the false file during the team's briefing with the FBI to keep his scheme from coming to light. He combines the various appliances into a giant robot, which overpowers the police. Darwin falls from above, losing the PDA in the process, but Hurley saves him and uses his weight to lift Darwin up to the robot. Darwin tries to convince Speckles to change his ways, reminding him of how Ben took them in and made them a real family. Realizing his plan will cost him the only family he has left, Speckles unsuccessfully attempts to shut down the system. Mooch recovers the PDA and Darwin uploads the virus to the main server, destroying the robot, while Juarez saves them from falling. They later find Hurley under the ruins, injured and unconscious. Darwin states that Hurley's actions were truly heroic, and finally acknowledges him as his brother. Hurley regains consciousness and becomes a member of the team. G-Force receives personal recognition from the FBI Director, who tells them that Saber has been assigned to recall all his products, while Speckles is given the duty of removing the microchips before rejoining the team. Killian is relocated to an FBI base on the
South Pole as a punishment for trying to arrest G-Force. The FBI gives full support to Ben's program, with Bucky and the mice joining it, and Darwin, Blaster, Juarez, and Hurley become official FBI Special Agents. ==Cast==