This gene encodes a member of the
phospholipase C family, which catalyze the hydrolysis of
phosphatidylinositol 4,5-bisphosphate to generate the second messengers
diacylglycerol and
inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing
protein kinase C and increasing cytosolic
Ca2+ concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by
spermine,
sphingosine, and several
phospholipids. == References ==