If {{math|{
p,
p + 2,
p + 6,
p + 8} }} is a prime quadruplet and or is also prime, then the five primes form a
prime quintuplet which is the closest admissible constellation of five primes. The first few prime quintuplets with are: :{{nowrap|{5, 7, 11, 13, 17},}} {{nowrap|{11, 13, 17, 19, 23},}} {{nowrap|{101, 103, 107, 109, 113},}} {{nowrap|{1481, 1483, 1487, 1489, 1493},}} {{nowrap|{16061, 16063, 16067, 16069, 16073},}} {{nowrap|{19421, 19423, 19427, 19429, 19433},}} {{nowrap|{21011, 21013, 21017, 21019, 21023},}} {{nowrap|{22271, 22273, 22277, 22279, 22283},}} {{nowrap|{43781, 43783, 43787, 43789, 43793},}} {{nowrap|{55331, 55333, 55337, 55339, 55343} }} … . The first prime quintuplets with are: :{{nowrap|{7, 11, 13, 17, 19},}} {{nowrap|{97, 101, 103, 107, 109},}} {{nowrap|{1867, 1871, 1873, 1877, 1879},}} {{nowrap|{3457, 3461, 3463, 3467, 3469},}} {{nowrap|{5647, 5651, 5653, 5657, 5659},}} {{nowrap|{15727, 15731, 15733, 15737, 15739},}} {{nowrap|{16057, 16061, 16063, 16067, 16069},}} {{nowrap|{19417, 19421, 19423, 19427, 19429},}} {{nowrap|{43777, 43781, 43783, 43787, 43789},}} {{nowrap|{79687, 79691, 79693, 79697, 79699},}} {{nowrap|{88807, 88811, 88813, 88817, 88819} }}... . A prime quintuplet contains two close pairs of twin primes, a prime quadruplet, and three overlapping prime triplets. The first prime of a quintuplet starting above 5 will end with the digit
1 or
7 in base 10 and the last prime will end with the digit
3 or
9. It is not known if there are infinitely many prime quintuplets. Once again, proving the twin prime conjecture might not necessarily prove that there are also infinitely many prime quintuplets. Also, proving that there are infinitely many prime quadruplets might not necessarily prove that there are infinitely many prime quintuplets. The
Skewes number for prime quintuplets {{math|{
p,
p + 2,
p + 6,
p + 8,
p + 12} }} is 21432401 (). ==Prime sextuplets==