Saint-Ruf grew rapidly, acquiring many
priories through donations.
Pope Urban II confirmed its properties and approved its customs in 1092, the first time a pope had formally approved the vocation of the canons regular. In 1084, two canons of Saint-Ruf were among the six companions of
Bruno the Carthusian when he founded
Grande Chartreuse. In 1085, a monk of Saint-Ruf named was elected
bishop of Barcelona. Abbot Arbert himself was elected
bishop of Avignon in 1096. He was succeeded as abbot by
Lietbert. In 1107, the canon
Berengar was elected
bishop of Orange. In 1111,
Olegarius was elected abbot, but he left in 1116 to become bishop of Barcelona. Lietbert wrote a new version of the customary, the
Liber ordinis. He also wrote a commentary on the
Regula tertia, the third rule of Saint Augustine. As a result, when the stricter
Ordo monasterii or second rule of Saint Augustine came into vogue, the abbey of Saint-Ruf stuck to the
Regula tertia. The cathedral chapters of
Maguelone,
Mende,
Uzès,
Tortosa and
Tarragona adopted the customs of Saint-Ruf. Its customs also influenced those of , ,
Rottenbuch, and
Aureil. The
monastery of the Holy Cross in Coimbra, Portugal, adopted its customs. In the wake of the
First Crusade, Saint-Ruf was granted a church and lands in the
County of Tripoli by Count
Raymond I, but this acquisition was ephemeral. Between 1143 and 1147 English monk Nicholas Breakspear was elected abbot. He traveled to Catalonia, where he was present at the
siege of Tortosa (1148) and acquired a church in Barcelona. In 1150, he was made a cardinal and in 1154 was elected
Pope Adrian IV. In 1158, the headquarters of the order was moved to . ==Decline==