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Psilocybin mushroom

Psilocybin mushrooms are a type of hallucinogenic mushroom and a polyphyletic informal group of fungi that contain a prodrug of psilocybin, which turns into the psychedelic psilocin upon ingestion. Rather than referring to one single mushroom species, the term “psilocybin mushroom” refers to a broad group of fungi found across several genera. Other compounds such as baeocystin, norbaeocystin, aeruginascin, and β-carbolines may modulate effects. The most potent species are members of genus Psilocybe, such as P. azurescens, P. semilanceata, and P. cyanescens, but psilocybin has also been isolated from approximately a dozen other genera, including Panaeolus, Inocybe, Pluteus, Gymnopilus, and Pholiotina.

Natural occurrence
In a 2000 review on the worldwide distribution of psilocybin mushrooms, Gastón Guzmán and colleagues considered these distributed among the following genera: Psilocybe (116 species), Gymnopilus (14), Panaeolus (13), Copelandia (12), Pluteus (6) Inocybe (6), Pholiotina (4) and Galerina (1). Guzmán increased his estimate of the number of psilocybin-containing Psilocybe to 144 species in a 2005 review. Many of them are found in Mexico (53 species), with the remainder distributed throughout Canada and the US (22), Europe (16), Asia (15), Africa (4), and Australia and associated islands (19). Psilocybin mushrooms occur on all continents, but the majority of species are found in subtropical humid forests. Psilocybe cubensis grows naturally in tropical and subtropical conditions, often near cattle due to the ideal conditions they provide for the growth of the fungus. The cow usually consumes grains or grass covered with the spores of P. cubensis, and the fungus will begin to germinate within the dung. Psilocybin-containing mushrooms occupy a variety of ecological niches depending on the species and genus. Some species are commonly associated with decomposing wood, grasslands, forest soils, mossy environments, or animal dung. Scientists also classify these fungi using both visible mushroom traits and newer DNA-based methods, which has helped improve identification and distinguish psychoactive species from similar-looking non-psychoactive or potentially toxic mushrooms. Ecologically, these fungi are generally saprotrophs, meaning they obtain nutrients by breaking down dead organic material in their environments. This helps explain why many species are found on decaying wood, plant litter, rich soils, or dung-based substrates.. Habitat also differs by genus. Species of Panaeolus are especially associated with dung-rich habitats and grasslands, while many Pluteus and Gymnopilus species are more often linked to decaying wood and woody debris.' Recent phylogenomic research has also increased scientific interest in the possible ecological role of psilocybin itself. One proposed idea is that psilocybin may be involved in fungal interactions with insects, although researchers have also noted that direct empirical evidence for this remains limited. Geographic records are still incomplete in many regions, and recent studies have emphasized that global biodiversity data for psychedelic fungi remain uneven. This means the currently documented distribution of psilocybin-containing mushrooms may still underestimate their full ecological range. ==Composition==
Composition
Magic mushroom composition varies from genus to genus and species to species. Its principal component is psilocybin, which is converted into psilocin to produce psychoactive effects. Besides psilocin, norpsilocin, baeocystin, norbaeocystin, and aeruginascin may also be present, which might result in an entourage effect and modify the effects of magic mushrooms. Panaeolus subbalteatus, one species of magic mushroom, had the highest amount of psilocybin compared to the rest of the fruiting body. Cyclocybe, and Hygrophorus. Harmine, harmane, norharmane, and a range of other β-carbolines were discovered in Psilocybe species. β-Carbolines in psilocybin mushrooms may inhibit the metabolism of psilocybin and other constituents and thereby potentiate their effects. ==Uses==
Uses
Psilocybin-containing mushrooms may be used in whole form, for example consumption of dried or fresh mushrooms, or may be turned into extracts or food products such as mushroom edibles or mushroom tea. Psilocybin-containing mushrooms and products, as well as products containing related compounds like 4-AcO-DMT, may be purchased at smart shops like psychedelic mushroom stores in some jurisdictions. Another related psilocybin-containing fungus is magic truffles, which are not technically mushrooms themselves but are the sclerotia or mycelium of psilocybin-containing mushrooms. Dosing The dose of psilocybin-containing mushrooms depends on the psilocybin and psilocin content, which can vary significantly between and within the same species. Psilocybin content is typically around 0.5% to 1% of the dried weight of the mushroom, with a range of 0.03% to 1.78%. Psilocin is also often present in the mushrooms, with a range of 0% to 0.59%, and can be on par with or an order of magnitude lower than psilocybin levels. The 'Penis Envy' strain of P. cubensis is considered to be more potent than other strains. Recreational doses of psilocybin mushrooms are typically between 1.0 and 3.5–5.0g of dry mushrooms and 10 to 50g of fresh mushrooms. This corresponds to a dose of psilocybin of about 10 to 50mg. A 5.0g dose of dried mushroom is often referred to as a "heroic dose". In terms of psilocybin dosing, subthreshold or microdoses are <2.5mg, low doses are 5 to 10mg, the intermediate or "good effect" dose is 20mg, and high or ego-dissolution doses are 30 to 40mg. Microdosing has become a popular technique for many users, which involves taking <1.0g of dried mushrooms for an experience that is not as intense or powerful, but recreationally enjoyable, or fully non-hallucinogenic, and potentially alleviating for symptoms of depression. It involves soaking psilocybin-containing mushrooms in citric acid-containing lemon juice to supposedly convert their psilocybin content into psilocin prior to administration. This is claimed to hasten their onset, cause a sharper and more intense peak, and shorten their duration. ==Effects==
Effects
study ranking various drugs (legal and illegal) based on statements by drug-harm experts. This study rated "mushroom" the least harmful drug overall and for users, and the only drug that did not get any scores for harm on others. The effects of psilocybin mushrooms come from psilocybin and psilocin. When psilocybin is ingested, it is broken down by the liver in a process called dephosphorylation. The resulting compound is called psilocin, responsible for the psychedelic effects. Psilocybin mushrooms have not been known to cause physical or psychological dependence (addiction). Noticeable changes to the auditory, visual, and tactile senses may become apparent around 30 minutes to an hour after ingestion, although effects may take up to two hours to take place. These shifts in perception visually include enhancement and contrasting of colors, strange light phenomena (such as auras or "halos" around light sources), increased visual acuity, surfaces that seem to ripple, shimmer, or breathe; complex open and closed eye visuals of form constants or images, objects that warp, morph, or change solid colors; a sense of melting into the environment, and trails behind moving objects. Sounds may seem to have increased clarity—music, for example, can take on a profound sense of cadence and depth. Emotional effects As with other psychedelics such as LSD, the experience, or 'trip,' is strongly dependent upon set and setting. The psychological consequences of psilocybin use include hallucinations and an inability to discern fantasy from reality. Panic reactions and psychosis also may occur, particularly if a user ingests a large dose. Recent research has also increased interest in the possible therapeutic effects of psilocybin in controlled settings, especially for depression, anxiety, and substance use disorders, though current findings are still being studied and should be interpreted carefully. ==Contraindications==
Toxicity
'' The species within the most commonly foraged and ingested genus of psilocybin mushrooms, the psilocybe, contains two primary hallucinogenic toxins; psilocybin and psilocin. The median lethal dose, also known as "LD50", of psilocybin is 280 mg/kg. From a toxicological profile, it would be incredibly difficult to overdose on psilocybin mushrooms, given their primary toxin compounds. To consume such massive amounts of psilocybin, one must ingest more than of dried Psilocybe cubensis given 1-2% of the dried mushroom contains psilocybin. A 2015 study observed that a dose of 200 mg/kg psilocin induced symptoms of acute serotonin poisoning in mice. Neurotoxicity-induced fatal events are uncommon with psilocybin mushroom overdose, as most patients admitted to critical care are released from the department only requiring moderate treatment. A more common public health concern than overdose is accidental misidentification, since some psychoactive mushroom species can resemble non-psychoactive or toxic mushrooms. ==Interactions==
History
Early The use of psilocybin mushrooms by humans in religious ceremonies dating back thousands of years is contested. Despite popular narratives portraying psychedelics as ancient, widespread, and primarily used by shamans for therapeutic healing, careful anthropological and historical research shows their traditional use was limited, recent, and culturally specific, with modern Western interpretations largely shaped by idealization, tourism, and ideological agendas. 6,000-year-old pictographs discovered near the Spanish town of Villar del Humo illustrate several mushrooms that have been argued to be Psilocybe hispanica, a hallucinogenic species native to the area. Some scholars have also interpreted archaeological artifacts from Mexico and the so-called Mayan "mushroom stones" of Guatemala as evidence of ritual and ceremonial use of psychoactive mushrooms in the Mayan and Aztec cultures of Mesoamerica. The hallucinogenic species of the Psilocybe genus have a history of use among the native peoples of Mesoamerica for religious communion, divination, and healing, from pre-Columbian times to the present day. Aztecs and Mazatecs referred to psilocybin mushrooms as genius mushrooms, divinatory mushrooms, and wondrous mushrooms when translated into English. Bernardino de Sahagún reported the ritualistic use of teonanácatl by the Aztecs when he traveled to Central America after the expedition of Hernán Cortés. The Spanish believed the mushroom allowed the Aztecs and others to communicate with demons. Despite this history, the use of teonanácatl has persisted in some remote areas. Anecdotal reports suggests the mushroom was used spiritually and traditionally by Basotho healers, marking it the only documented instance of traditional hallucinogenic mushroom use in Africa and the earliest recorded reference to such practices in Sub-Saharan Africa. This experiment reviewed the subjects six months later, and found that the recidivism rate had decreased beyond their expectation, below 40%. This, and another experiment administering psilocybin to graduate divinity students, showed controversy. Shortly after Leary and Alpert were dismissed from their jobs by Harvard in 1963, they turned their attention toward promoting the psychedelic experience to the nascent hippie counterculture. ==Society and culture==
Society and culture
Legal status The legality of the cultivation, possession, and sale of psilocybin mushrooms and psilocybin and psilocin varies from country to country. After Oregon Measure 109, in 2020, Oregon became the first US state to decriminalize psilocybin and legalize it for therapeutic use. However, selling psilocybin without being licensed may still attract fines or imprisonment. In 2022 Colorado legalized consumption, growing, and sharing for personal use, though sales are prohibited while regulations are being drafted. Other jurisdictions in the United States have decriminalized psilocybin mushrooms. Furthermore, buying spores of mushroom species containing psilocybin online in the United States is legal in all states except Georgia, Idaho and California. This is because only fruiting mushrooms and mycelium contain psilocybin, a federally banned substance. A technical caveat to consider, however, is that the distributed spores must not be intended to be used for cultivation, but allowed for microscopy purposes. United Nations Internationally, mescaline, DMT, and psilocin, are Schedule I drugs under the Convention on Psychotropic Substances. The Commentary on the Convention on Psychotropic Substances notes, however, that the plants containing them are not subject to international control: == Research ==
Research
Due partly to restrictions of the Controlled Substances Act, research in the United States was limited until the early 21st century when psilocybin mushrooms were tested for their potential to treat drug dependence, anxiety and mood disorders. In 2018–19, the Food and Drug Administration (FDA) granted Breakthrough Therapy Designation for studies of psilocybin in depressive disorders. More recent review articles have expanded scientific interest in psilocybin-related research, especially in psychiatry, neuroscience, and psychopharmacology. Researchers have focused on possible applications involving depression, anxiety, and substance use disorders, while also emphasizing the need for continued controlled study. ==See also==
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