Charlotte was named
Princess of Antioch in 1456. The same year she married her first husband,
John of Portugal. The marriage might have been intitiated by John's aunt
Isabella of Portugal, Duchess of Burgundy, in order to acquire a naval base in the Mediterannean for safe passage of bands of Burgundian
Crusaders into the
Holy Land. Charlottes husband tried to counterbalance the Greek Orthodox influence of his mother-in-law, Helena Palaiologina. But after a time the relationship between John and Helena became so strained that he and Charlotte moved to the home of
Peter of Lusignan. After a short illness (allegedly due to poisoning by Helena), he died in 1457 and was buried in the Church of St. Francis in Nicosia. Now a young widow, Charlotte's loss was followed the very next year by the death of her father on 28 July 1458 . At the age of fourteen Charlotte thus became
Queen of Cyprus and was crowned at St. Sophia Cathedral on 7 October 1458. Charlotte's reign was not successful. She had a tenuous hold on the kingdom, as her right to the throne was constantly being challenged by her illegitimate half-brother James. On 7 October 1459, she married her second husband,
Louis of Savoy, Count of Geneva. This marriage had been arranged by the Genoese, who promised their assistance in retaining her crown against the claims by James. Her half-brother was crowned King James II. She took up residence at the Convertendi Palace in
Trastevere.
Pope Pius II, who was acquainted with her described Charlotte as "a woman of about twenty-four, of middle height: bright eyes, complexion betwixt dark and pale; speech smooth and flowing torrent like after the manner of the Greeks; French costume; manners becoming her royal blood". She later formed a small court on the Greek island of
Rhodes. She made an unsuccessful military attempt to regain her throne with papal support. She also intrigued against James's widow,
Catherine Cornaro, but failed to oust her from power. In November 1483 she was received by
Pope Sixtus IV in the
Vatican Palace and was seated in a chair of the same "height and dignity" as the pope. In
Rome, she lived in a house in
Piazza Scossacavalli in
Borgo which had already hosted queen
Catherine of Bosnia. ==Succession and death ==