Most documented cases of
chronic traumatic encephalopathy have occurred in many athletes involved in
contact sports such as
boxing,
American football,
professional wrestling,
ice hockey,
mixed martial arts,
rugby, and
soccer. Other risk factors include being in the military, prior
domestic violence, and
repeated banging of the head. Omalu, initially a medical examiner, then associate adjunct professor in California, was a co-founder of the
Brain Injury Research Institute and reportedly in 2012 participated in the autopsy of
Junior Seau. Omalu's participation was halted during the autopsy after Seau's son Tyler Seau, under pressure from the NFL, revoked previously provided oral permission. Tyler had received telephone calls from NFL management denouncing Omalu's professional ethics, qualifications, and motivation when the league asked him to revoke Dr. Omalu's research. Research into football players with CTE has continued with
neuropathologist Ann McKee of Boston University's CTE Center, who diagnosed the bodies of twelve former professional
American football players with CTE postmortem between 2008 and 2010. An autopsy McKee conducted in 2010 on the brain of Owen Thomas, a 21-year-old junior lineman at the
University of Pennsylvania who died of suicide, showed early stages of CTE, making him the second youngest person at the time to be diagnosed with the condition. Thomas was also the second amateur football player diagnosed with CTE. (Mike Borich, who died at 42, had been the first such player diagnosed with CTE, also by McKee.) The doctors who performed the autopsy indicated that they found no causal connection between Thomas's early-stage CTE and his suicide. There was no indication that Thomas missed playing time due to concussions; however, as a player who played hard and "loved to hit people," Thomas may have played through concussions and received thousands of subconcussive impacts on the brain. On May 2, 2012, retired twelve-time Pro Bowler
Junior Seau died of suicide from a gunshot wound to the chest. There was speculation that he had brain damage due to CTE. Seau's family donated his brain tissue to the
National Institute of Neurological Disorders and Stroke. On January 10, 2013, the brain pathology report was released, and Seau's brain showed evidence of CTE. Seven months after Seau's death, on December 1, 2012,
Kansas City Chiefs linebacker
Jovan Belcher killed his girlfriend, then drove to
Arrowhead Stadium and killed himself in front of then-GM
Scott Pioli and then-head coach
Romeo Crennel. A year later, on behalf of Belcher's minor daughter, a family lawyer filed a wrongful-death lawsuit against the Chiefs, alleging that the team deliberately ignored warning signs of CTE, possibly leading to Belcher's suicide. The lawyer also hired a medical examiner to examine Belcher's brain for signs of CTE. On September 29, 2014, it was confirmed that he had CTE. Coverage of Belcher's murder-suicide, combined with the suicide of Junior Seau, drew national attention to CTE and its effects on the brains of football players. In September 2015, researchers with the
United States Department of Veterans Affairs and Boston University announced that they had identified CTE in 96 percent of
National Football League players that they had examined and in 79 percent of all football players. By November 2016, 90 of 94 former NFL players had been posthumously diagnosed with CTE by McKee. Professional players diagnosed included eight-time Pro Bowler
Lou Creekmur,
Cookie Gilchrist and
Wally Hilgenberg. In March 2016, former NFL running back
Kevin Turner, who played for the New England Patriots and
Philadelphia Eagles, died at age 46. Earlier, in 2010, he had been diagnosed with
amyotrophic lateral sclerosis (ALS). But after his death, his brain was donated to
Boston University Brain CTE Center, which diagnosed Turner with a severe case of CTE and stated that it was CTE, not ALS, that had killed him. However, there has been research into the connections of both CTE and ALS. In April 2017, former
New England Patriots tight end
Aaron Hernandez died by suicide in prison at age 27. On September 21, 2017, an
autopsy report from
Boston University identified Stage 3 CTE in Hernandez's brain. Until Hernandez's autopsy, researchers had never seen Stage 3 CTE in a brain younger than 46 years old. The
Journal of the American Medical Association released an updated study in July 2017 reporting that out of 111 brains of deceased former NFL players studied, 110 (99%) had CTE. This also led to players retiring very early in their careers. As of December 2018, 87% of the 202 American football players' brains that have been donated to Boston University tested positive for CTE.
O. J. Simpson was suspected of having chronic traumatic encephalopathy before his death in 2024. After his death, Scientists had requested for Simpson's brain to be studied for signs of CTE, but the Simpson estate refused, who announced that his whole body will be cremated instead. A recent 2024 study focusing on the quantitative characteristics of the brain in American Football players have identified structural brain differences in former American football players when compared to same-age men without a history of
traumatic brain injury (TBI) or participation in sports.These safety reforms also led to the establishment of the Intercollegiate Athletic Association of the United States, which was later renamed the
National Collegiate Athletic Association. In 1964, the NCAA produced a policy that required football players to wear
mouthguards during play. The mouthguard works to not only protect the teeth but also to prevent concussions by absorbing impact forces instead of letting force travel to the base of the skull and then consequently to the brain. The number of full-contact practice sessions teams run has been reduced, based on the 2011 collective bargaining agreement. In 2012, some four thousand former NFL players "joined civil lawsuits against the League, seeking damages over the League's failure to protect players from concussions, according to Judy Battista of the [New York]
Times." In 2013 the NFL settled with a class-action lawsuit. The NFL supposedly hid the long-term effects of concussions. The NFL didn't admit to hiding anything, but they gave money to retired NFL football players who suffered from brain-related injuries from football. On August 30, 2013, the NFL reached a $765 million settlement with the former NFL players over the head injuries. The settlement created a $675 million compensation fund from which former NFL players can collect depending on the extent of their conditions. Severe conditions such as
Lou Gehrig's disease and postmortem-diagnosed chronic traumatic encephalopathy may be entitled to payouts as high as $5 million. In the settlement Brody did accept, she argued that people "cannot be compensated for C.T.E. in life because no
diagnostic or clinical profile of C.T.E. exists, and the symptoms of the disease, if any, are unknown." On April 22, 2015, a final settlement was reached between players and the NFL in the case adjudicated by Judge Brody. Terms include payments to be made by the NFL for $75 million for "baseline medical exams" for retired players, $10 million for research and education, as well an uncapped amount for retirees "who can demonstrate that they suffer from one of several brain conditions covered by the agreement," with total payments expected to exceed $1 billion over 65 years. On March 14, 2016, NFL's senior vice president of health and safety, Jeff Miller, publicly admitted that there is a link between football and CTE at the roundtable discussion on concussions. In an attempt to lower the number of
helmet-to-helmet hits, which often leads to concussions and increases likelihood of brain injuries, the NFL changed its rules for helmet-to-helmet hits in the offseason of 2018.
Boxing The introduction of CTE and its relationship with Boxing began in 1928 when Dr.
Harrison Stanford Martland discovered Punch Drunk Syndrome, the first label for Chronic Traumatic Encephalopathy, in boxers. Symptoms of CTE were often reported in boxers but unfortunately many boxers diagnosed with Punch Drunk Syndrome, Dementia Pugilistica, or CTE did not donate their brains for autopsy review. In 2005 approximately 77 years after its discovery there were fewer than 50 cases of brains with CTE found post mortem. British physician A.H. Roberts performed one of the first clinical assessments of traumatic encephalopathy in athletes in 1969. Such an assessment focused on retired professional boxers in the United Kingdom. Roberts drew a sample of 250 retired boxers from a total pool of 16,781 registered with the
British Boxing Board of Control between 1929 and 1955. Of the 250, 224 were successfully studied; 16 had died, 9 had emigrated, and 1 refused to participate. Roberts found that 17% of the boxers showed signs of neurological damage consistent with traumatic encephalopathy. Of these, 11% were classified as having a mild form of the condition, while 6% were identified with a more severe presentation. Roberts also noted that the severity of symptoms correlated with the length of a boxer's career and the number of matches they had participated in. He also noted that a small subset of boxers experienced progression of
Parkinsonian symptoms.
Jimmy Ellis,
Jerry Quarry, and
Jimmy Young,
Bobby Chacon,
Mike Quarry,
Emile Griffith,
Willie Pep, and
Billy Conn. Other cases of Boxers who have been speculated to have experienced CTE but not ever diagnosed with the condition were: "Terrible"
Terry McGovern,
Battling Nelson "the Durable Dane",
Muhammad Ali,
Fritzie Zivic,
Meldrick Taylor, and
Rocky Graziano. Boxers currently living with the symptoms of CTE as of 2021: "Irish"
Micky Ward, Alan Blyweiss "The Rock",
Wilfred Benitez, and
Herol Graham.
BMX In 2016,
BMX biker and extreme sport icon
Dave Mirra was diagnosed post-mortem with CTE. He died of suicide by gunshot on February 4, 2016, and his brain was examined by Lili-Naz Hazrati of the
University of Toronto, who confirmed the diagnosis. In addition to the "countless"
concussions he had during his career, his skull was fractured when he was hit by a car at 19 years old and he took up
boxing after retirement. He became the first
action sports star to be diagnosed with the
neurodegenerative disease.
Ice hockey Athletes from other sports have also been identified as having CTE, such as hockey player
Bob Probert. Neuropathologists at
Boston University diagnosed
Reg Fleming as the first hockey player known to have the disease. This discovery was announced in December 2009, six months after Fleming's death.
Rick Martin, best known for being part of the
Buffalo Sabres'
French Connection, was diagnosed with CTE after his brain was posthumously analyzed. Martin was the first documented case of an ice hockey player not known as an enforcer to have developed CTE; Martin was believed to have developed the disease primarily as a result of a severe concussion he received in 1977 while not wearing a helmet. The disease was low-grade and asymptomatic in his case, not affecting his cognitive functions. He died of a heart attack in March 2011 at the age of 59. Also within a few months in 2011, the deaths of three
hockey "enforcers"—
Derek Boogaard from a combination of too many painkillers and alcohol,
Rick Rypien, an apparent suicide, and
Wade Belak, who, like Rypien, was reportedly depressed; and all with a record of fighting, blows to the head and concussions—led to more concerns about CTE. Boogaard's brain was examined by BUSM, which in October 2011 determined the presence of CTE. One
National Hockey League player known in part for leading "the thump parade", former
Boston Bruin right winger
Shawn Thornton mulled over the "tragic coincidence" of the three recent league deaths and agreed that their deaths were due to the same cause, yet still defended the role of fighting on the rink. In 2016,
Stephen Peat, then 36 years old and formerly an enforcer for the
Washington Capitals during his professional career, was reported to be suffering severe symptoms of CTE. His father Walter was reported to worry that his son would join the "dead before turning 50 ... since 2010" list of enforcers including Boogaard, Rypien, Belak,
Steve Montador. In December 2017
Zarley Zalapski died, at the age of 49, after complications related to a viral infection. Following his death, his sister wanted to know if he had any brain issues and was confirmed to have CTE. In 1989,
Merril Hoge was a
Pittsburgh Steeler when Zalapski was a
Pittsburgh Penguin. The two were part of a civic helmet-safety campaign and posed for photos. A few years before Zalapski's death, his sister Kyla had reached out to Hoge to assist her brother who was struggling with his health to transition into retirement. In 2011,
USA hockey, which controls the rules surrounding youth hockey in the United States banned body checking along with checking at the head or neck for kids who are ages 13–14 or younger. This is supposed to help prevent youth hockey players from getting concussions and other injuries in youth hockey. In February 2015,
Steve Montador died unexpectedly, and the subsequent examination of Montador's brain by doctors at
Krembil Neuroscience Centre at
Toronto Western Hospital found a "widespread presence" of CTE. Montador joins the growing list of former ice hockey players discovered to have CTE which includes
Rick Martin,
Derek Boogaard, and
Reg Fleming.
Professional wrestling In 2007, neuropathologists from the Sports Legacy Institute (an organization co-founded by
Christopher Nowinski, himself a former professional wrestler) examined the brain of
Chris Benoit, a
professional wrestler with
WWE, who
killed his wife and son before committing suicide. The suicide and double murder were originally attributed to
anabolic steroid abuse, but a brain biopsy confirmed
pathognomonic CTE tissue changes: large aggregations of tau protein as manifested by
neurofibrillary tangles and
neuropil threads, which cause
neurodegeneration. In 2009,
Bennet Omalu discovered CTE in recently retired wrestler
Andrew "Test" Martin, who died at age 33 from an accidental drug overdose. On February 9, 2016,
Daniel Bryan was forced to retire early due to signs of CTE and post-concussion seizures. He was medically cleared to wrestle again on March 20, 2018. After their deaths in February and April 2016 respectively, former ECW wrestlers
Axl Rotten and
Balls Mahoney were found to have had CTE. In July 2016, 53 professional wrestlers, represented by Konstantin Kyros, filed a lawsuit against WWE, looking to hold the organization accountable for their "long-term neurological injuries" due to multiple concussions and CTE. In November 2017, as part of filing an amended version of the lawsuit, Kelli Sloan and Shirley Fellows were added to the class-action documents, as they represented deceased wrestlers diagnosed with CTE, with Sloan representing her father
Harry (Mr. Fuji) Fujiwara and Fellows her son
Timothy Well.
Carole Snuka, initially part of the first filing, also used the second filing to note her husband, whom she represented in the litigation, subsequently died and was also diagnosed with CTE. The lawsuit was dismissed on September 14, 2018, by US district judge
Vanessa Lynne Bryant. An appeal was filed but the
United States Court of Appeals for the Second Circuit dismissed it on September 9, 2020. and James Leahy suffer from CTE as a result of repeated head trauma during their fighting careers. In keeping with other recorded instances of delayed onset, Leahy's symptoms developed years after his retirement from martial arts. In October 2016,
Bennet Omalu announced that CTE had been posthumously detected in the brain of MMA fighter
Jordan Parsons. In 2018,
Wanderlei Silva admitted to experiencing symptoms consistent with CTE and expressed a wish to donate his brain for research.
Association football In 2012, Patrick Grange, a semi-professional footballer, was diagnosed in an autopsy with Stage 2 CTE with motor neuron disease. "The fact that Patrick Grange was a prolific
header is important",
Christopher Nowinski, co-founder of the Sports Legacy Institute, said in an e-mail. "We need a larger discussion around at what age we introduce headers, and how we set limits to exposure once it is introduced." Grange played soccer in high school; college at Illinois-Chicago and New Mexico; in the
Premier Development League; for
Albuquerque Asylum; and for
Chicago Fire Premier. He died of
ALS at age 29 in 2012 with a posthumous diagnosis of CTE. In 2014, Brazilian footballer
Hilderaldo Bellini was posthumously diagnosed with CTE. Bellini helped lead Brazil to
FIFA World Cup victories in 1958 and 1962, and he was the team's captain in the first one. In 2017, a study identified CTE in four former association footballers known to be skilled
headers. English midfielder,
Nobby Stiles, who died in October 2020, was diagnosed post-mortem as having chronic CTE caused by repeated blows to the head, and the disease was highly likely to have caused the dementia that he suffered in later life. During his career at
Manchester United, Stiles headed a ball more than 70,000 times.
Rugby union Researchers found Australian rugby union player Barry "Tizza" Taylor died in 2013 of complications of severe CTE with dementia at age 77. Taylor played for 19 years in amateur and senior leagues before becoming a coach.
Rugby league An Australian study of 25 retired
NRL players showed they had impaired reaction times and concentration compared to the general population. This included
Kangaroos player
Ian Roberts who had been knocked unconscious 14 times over his professional career. In 2022, former player
Paul Green died at the age of 49. A neuropathologist professor stated Green had one of the most severe cases of CTE they'd ever seen.
Australian football Analysis of the late
Australian rules football player
Danny Frawley's brain revealed that he had stage two chronic traumatic encephalopathy (CTE) at the time of his death in 2019.
Australian rules football player
Greg Williams is thought to have CTE as a result of concussions over a 250-game career. In March 2016
Justin Clarke of the
Australian Football League (AFL) team the
Brisbane Lions was forced to retire at just 22 years of age due to a serious concussion sustained during off-season training two months earlier. He was the fifth AFL player in the previous ten months to retire with concussion related injuries, with
Sam Blease (25 yo,
Melbourne and
Geelong),
Jack Fitzpatrick (26 yo, Hawthorn and
Melbourne Football Club),
Leigh Adams (27 yo,
North Melbourne),
Matt Maguire (32 yo, Brisbane and
St Kilda), and
Brent Reilly (32 yo,
Adelaide) all having retired since May 2015. All the retirements were linked to a crackdown on head injuries by the AFL and fears of CTE associated with local and international sportspeople, especially American footballers. In 2021, an analysis of former
Australian rules football player
Shane Tuck revealed that he was suffering from stage three CTE, up to his suicide in 2020. This made him the third player to be diagnosed with CTE.
Baseball In 2012, the brain tissue of
Ryan Freel was tested after his death. It was found that he had Stage 2 CTE. Freel was the first Major League Baseball player to be diagnosed with chronic traumatic encephalopathy. After the 2012 season, the
MLB instituted the
Buster Posey rule. The rule is intended to reduce injuries, concussions in particular, caused by home-plate collisions between catchers and baserunners.
Canadian football On January 10, 2011, former AFL and Canadian football player through the years of 1956 to 1967
Cookie Gilchrist died. Gilchrist was diagnosed with stage four CTE by
Boston University.
Rodeo In 2017, Ty Pozzobon, who at the age of 25 years also committed suicide, became the first
professional bull rider diagnosed with the disease. Within ten years, he had received 15 head injuries and his first concussion at the age of 16. == Young Adults ==