Radnor was cast as the lead in
The WB series
Off Centre. However, the role was re-cast with
Eddie Kaye Thomas before the first episode aired. In 2002, he made his
Broadway debut in the stage version of
The Graduate, succeeding
Jason Biggs, opposite
Kathleen Turner and
Alicia Silverstone. In 2004, Radnor starred in
The Paris Letter alongside his future
How I Met Your Mother co-star
Neil Patrick Harris. From 2005 to 2014, Radnor starred as
Ted Mosby in the
CBS sitcom How I Met Your Mother, his biggest role to date. The series ran for nine seasons and revolved around friends living in
New York City and finding love. He acted alongside
Cobie Smulders,
Neil Patrick Harris,
Jason Segel, and
Alyson Hannigan. In July 2008, he starred opposite
Jennifer Westfeldt in the premiere of the play
Finks, written by Joe Gilford and directed by Charlie Stratton for New York Stage and Film. Radnor made his directorial debut with the film
Happythankyoumoreplease, where he was both the writer and star of the 2010 comedy-drama. His second directorial effort,
Liberal Arts, starring himself and
Elizabeth Olsen, premiered at the
Sundance Film Festival on January 22, 2012. Radnor appeared in the
Broadway production of
Disgraced, which opened October 23, 2014, at the
Lyceum Theatre. He is set to direct the sci-fi thriller film
The Leaves. From 2016 to 2017 he played Dr. Jedediah Foster in the historical medical drama
Mercy Street on
PBS. In October 2016, Radnor also confirmed he is in a band,
Radnor and Lee, with Australian musician
Ben Lee. Radnor and Lee had known each other for "twelve or thirteen years after meeting on the set of
How I Met Your Mother" eventually writing songs together. Their debut album,
Radnor & Lee was released on November 10, 2017, "receiving widespread praise across the board, and cementing the duo as an accomplished pair of artists," stated
Rolling Stone. On February 19, 2020,
Spin announced
Radnor and Lee's sophomore album,
Golden State, out on Flower Moon Records, and premiered the first single "Outside In." American Songwriter later premiered the video for the album's 2nd single, "Simple Harmony." Due to the
COVID-19 pandemic, the album's release date was pushed back to June 2020. Radnor's debut solo EP, ''One More Then I'll Let You Go,'' was released on April 16, 2021, on Flower Moon Records.
Rolling Stone premiered the first single, "The High Road," March 10, 2021, calling it a "gently lilting ballad about the breakdown of a friendship on which he sings... which features deep textures of piano, acoustic guitar, organ, and snapping fingers." The EP's 2nd single, "You Feel New," premiered on March 31, 2021, with features in
Rolling Stone,
NPR,
American Songwriter and
Paste Magazine. From 2020 to 2023, he starred as Lonny Flash
Amazon Prime series,
Hunters acting alongside
Logan Lerman and
Al Pacino. He voiced Durpleton in the
Netflix animated series
Centaurworld (2021). He took a recurring role as Adam one of the protagonists friends, in the
FX on Hulu limited series
Fleishman Is in Trouble (2022). He acted alongside
Jesse Eisenberg,
Lizzy Caplan, and
Adam Brody. The series went on to receive a nomination for the
Primetime Emmy Award for Outstanding Limited or Anthology Series. In 2024 Radnor returned to theatre starring in the
Itamar Moses play
The Ally directed by
Lila Neugebauer at
The Public Theatre. ==Personal life==